Hereditary Breast Cancer
Prevention Strategies for Women with BRCA1 or BRCA2 Mutations
Given the uncertain utility of screening programs (secondary prevention) in this high-risk population, some women consider undergoing surgical…
Hereditary Breast Cancer Summary
In summary, the identification of a germline BRCA mutation in a woman with breast or ovarian cancer should…
Clinical Aspects of BRCA-Associated Breast and Ovarian Cancer
From a clinical perspective, it is important to determine whether or not BRCA-associated malignancies are distinct, either in…
Surveillance Options for Individuals with BRCA1 or BRCA2 Mutations
Surveillance options for individuals with germline BRCA mutations are necessarily built on expert opinion. Unfortunately, there has been…
Cancer Risks in Individuals with a BRCA1 or BRCA2 Mutation
The identification of unaffected women with BRCA1 or BRCA2 mutations provides an opportunity to reduce cancer mortality by…
Other Causes of Hereditary Breast Cancer
It is important to bear in mind that not all families with a pedigree suggestive of hereditary breast…
Probability of Detecting Mutations in BRCA1 or BRCA2
The probability of detecting a BRCA mutation in a given individual varies greatly with the clinical scenario. In…
Ethnic Status and Mutation Prevalence - Hereditary Breast Cancer
Ethnic status strongly influences the probability of detecting a mutation in BRCA1 or BRCA2. In the United States,…
Functions of BRCA1 and BRCA2 and the Mechanism of Hereditary Susceptibility
The functions of BRCA1 and BRCA2 are incompletely defined. The genes share little sequence homology, although there are…
Hereditary Breast Cancer and the Identification of BRCA1 and BRCA2
There are several possible explanations for the observed tendency of breast cancer to cluster in families. Chance may…
Hereditary Breast Cancer
Familial Breast Cancer
A family history of breast cancer has been consistently recognized as one…
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