Cancer Risks in Individuals with a BRCA1 or BRCA2 Mutation

	Tweet

The identification of unaffected women with BRCA1 or BRCA2 mutations provides an opportunity to reduce cancer mortality by enrolling such ndividuals in intensive surveillance and prevention programs.

Such programs would appear to be justified by the significantly increased cancer risks aced by these women. Unfortunately, the exact degree to which risk is elevated remains a topic of active investigation. Current estimates of cancer risks among BRCA1 or BRCA2 heterozygotes are shown in Table 11.3. The lifetime breast cancer risk for a woman with a mutation in either gene is estimated to be 50-85%.

The higher estimates are generated by the study of families with dramatic pedigrees, such as those included in the Breast Cancer Linkage Consortium effort.

Table 11.2. Syndromes associated with increased breast cancer risk

Lower estimates arise from the study of less highly selected families. Risk estimates range widely due to differences in methods of ascertainment and penetrance calculation. In addition, unidentified genetic or environmental factors may exist that may be distributed differently in the reported study populations. Factors modulating cancer risks in this population are not well described but may be different from those that are operative in populations that do not have an inherited predisposition.

It is crucial to recognize that the Gail model or “Claus tables” may substantially underestimate breast cancer risk in hereditary breast-ovarian cancer families, and such models should not be used for this purpose.

Although there are few data, the contralateral breast cancer risk by age 70 in women with BRCA1 mutations who have undergone mastectomy for one breast cancer is estimated to be as high as 65% and is likely to be similar for BRCA2 heterozygotes. Male BRCA2 heterozygotes are estimated to have an up to 6% lifetime risk of breast cancer.

The estimated risk of ovarian cancer ranges between 15% and 65% for BRCA1 heterozygotes and between 10% and 20% for those with mutations in BRCA2. Women with mutations in either gene also appear to be at increased risk for fallopian tube cancer and primary peritoneal carcinoma, but the level of this risk is undefined. As with breast cancer risk, estimates of ovarian cancer risk may vary as a result of ascertainment biases, or as a consequence of unidentified environmental or genetic factors. Other cancers that may occur with increased frequency in hereditary breast cancer families include colon (BRCA1), prostate (BRCA1 and BRCA2), pancreas (BRCA2) and larynx (BRCA2).

Mark E. Robson
Breast conservation therapy for invasive breast cancer in Ashkenazi women with BRCA gene founder mutations. J Natl Cancer Inst 2003

References

RELATED STORIES:
Fibroadenoma of the Breast   Mammary-Duct Fistula   Breast cancer risk is increased in women with prenatal exposure to diethylstilbestrol   Radiation Therapy for Early-Stage Breast Cancer   Role of High-Dose Chemotherapy for High-Risk Breast Cancer   Invasion and Proteases   Sexuality and Breast Cancer Survivorship   Duct Ectasia   Prognosis   Assessment of Sexual Function in Breast Cancer Survivors   Breast Cancer & Risks of Pregnancy   The Breast Cancer Alternative Hypothesis   The Mammogram Report: The Breast Imaging Reporting and Data System (BI-RADS™) Lexicon   Dilemma of “Earlier” detection   Fibromatosis of the breast   Special Clinical Forms of Breast Cancer   Breast Cancer Prevention   Prophylactic Oophorectomy and breast cancer   Uterine or Ovarian Enlargement in patients with breast cancer   The surgical management of breast cancer   Breast Cancer Treatment - Surgery   Breast Imaging Summary

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]