Elucidation of the basic mechanisms involved in the pathogenesis of breast cancer and numerous potential applications await further study of BRCA1, BRCA2, and other breast cancer susceptibility genes.

Patients carrying…

Li-Fraumeni syndrome was first identified in 1969 in a description of four kindreds identified through children with sarcomas whose cousins or siblings also had childhood soft-tissue sarcomas and whose other relatives had excessive cancer occurrence.…

The study of clinical syndromes that include an increased incidence of breast cancer has provided insight into the mechanisms by which genetic mutations result in the development of breast cancer. The most frequently…

Two groups have analyzed data from the Cancer and Steroid Hormone (CASH) Study, a large case-control study initiated in 1981. In this study group, 11% of breast cancer patients reported a…

Even though researchers are beginning to understand the influence of genetic factors on the incidence of breast cancer in largely white, Western populations of women, very little is known about breast…

The first attempts to determine the influence of family history on breast cancer risk were published in the first half of the twentieth century. Although many of these studies have methodological…

Introduction
Although noninherited factors certainly play a major role in familial clustering of breast cancer, breast cancer susceptibility genes appear directly responsible for 5% to 10% of all breast cancer. Much…