Breast Cancer Causes

Li-Fraumeni Syndrome

Li-Fraumeni syndrome was first identified in 1969 in a description of four kindreds identified through children with sarcomas…    

Future Directions in Breast Cancer Genetics

Elucidation of the basic mechanisms involved in the pathogenesis of breast cancer and numerous potential applications await further…    

Hereditary Breast Cancer Syndromes

The study of clinical syndromes that include an increased incidence of breast cancer has provided insight into the…    

How Much Breast Cancer is Inherited?

Two groups have analyzed data from the Cancer and Steroid Hormone (CASH) Study, a large case-control study initiated…    

Familial Breast Cancer in Nonwhite Populations

Even though researchers are beginning to understand the influence of genetic factors on the incidence of breast cancer…    

Epidemiologic Studies of Familial Breast Cancer

The first attempts to determine the influence of family history on breast cancer risk were published in the…    

Breast Cancer Inherited Genetic Factors

Introduction
Although noninherited factors certainly play a major role in familial clustering of breast cancer, breast…    

Epidemiology and Nongenetic Causes of Breast Cancer

Introduction
Breast cancer has an enormous impact on the health of women. Approximately 180,000 women…    

Prevention of Breast Cancer

Approaches for the primary prevention of breast cancer according to period of life are discussed here briefly and…    

Attributable Risk: The Quantitative Contribution of known risk factors

As noted in the first section of this chapter, the search for specific breast cancer risk factors has…    

Etiologic Summary

Much is known about the behavioral factors that influence breast cancer risk, and the links between these factors…    

Occupation - Epidemiology and Nongenetic Causes of Breast Cancer

A review of 115 studies conducted between 1971 and 1994 found little support for an association between specific…    

Environmental Pollution

Evidence of geographic variation in incidence and mortality rates of breast cancer within the United States, the steady…    

Ionizing Radiation

Ionizing radiation to the chest in moderate to high doses (e.g., 1 to 3 Gy) at a young…    

Physical Activity

Regular physical activity has been hypothesized to prevent breast cancer, largely by reducing circulating levels of sex hormones.…    

Diet and Breast Cancer Survival

Regardless of whether diet is related to the occurrence of breast cancer, if postdiagnosis diet were related to…    

Other Dietary Constituents

Alcohol
Although the association between alcohol consumption and breast cancer risk has been controversial, substantial…    

Dietary Fiber - Dietary Factors

Diets high in fiber have been hypothesized to protect against breast cancer, perhaps due to inhibition of the…    

Dietary Factors

Nutritional factors have been prominent among the environmental determinants of breast cancer hypothesized to account for the large…    

Low-Penetrance Genotypes and Gene-Environment Interactions

Family history of breast cancer in a first-degree relative is a consistent risk factor; risk increases with earlier…