You are here : health.am > Cancer Health Center > Breast Cancer Breast Cancer Other Causes of Hereditary Breast Cancer • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 It is important to bear in mind that not all families with a pedigree suggestive of hereditary breast cancer are linked to BRCA1 or BRCA2. Alterations in other genes, such as… Ethnic Status and Mutation Prevalence - Hereditary Breast Cancer • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 Ethnic status strongly influences the probability of detecting a mutation in BRCA1 or BRCA2. In the United States, Jewish women do not, as a group, manifest a significantly… Probability of Detecting Mutations in BRCA1 or BRCA2 • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 The probability of detecting a BRCA mutation in a given individual varies greatly with the clinical scenario. In two population-based series of unselected breast cancer cases, the rate of… Functions of BRCA1 and BRCA2 and the Mechanism of Hereditary Susceptibility • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 The functions of BRCA1 and BRCA2 are incompletely defined. The genes share little sequence homology, although there are some similarities in exon structure. The susceptibility… Hereditary Breast Cancer and the Identification of BRCA1 and BRCA2 • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 There are several possible explanations for the observed tendency of breast cancer to cluster in families. Chance may cause a common disorder such as breast cancer to… Hereditary Breast Cancer • Breast Cancer • • Hereditary Breast Cancer • Jun 13 08 Familial Breast Cancer A family history of breast cancer has been consistently recognized as one of the most important risk factors for the disease. Various studies have suggested that between 15-25% of… Molecular Biology of Preliferative Breast Disease • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 A number of genes have been identified as putative oncogenes in breast cancer based on expression in breast cancer and correlation with prognosis or as tumor suppressor genes by LOH. A… Conclusion - Biology of High Risk Benign Breast Lesions • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 The number of genetic alterations seen in breast cancer makes the task of constructing a model of genetic progression daunting. In general, the cUnician pays little attention to… Experimental Model for human proliferative Breast Disease • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 Recently, we established a new and unique model of early human breast cancer progression. This model, which is called “MCFIOAT”, consists of preneoplastic human breast epithelial cells that are able… Other Suppressor Genes • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 A number of other suppressor genes have been implicated in breast cancer. Nm23, originally characterized as a metastasis suppressor gene, has been reported to be uniformly expressed in all epithehal cells of benign… Estrogen Receptor • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 To many, progression of breast cancer and loss of estrogen receptor (ER) are synonymous. The perception is that normal breast tissue is ER*, is growth stimulated by estrogen, and is dependent upon estrogen for growth.… Invasion and Proteases • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 An increase in expression of enzymes capable of degrading basement membranes and extracellular matrix would be expected to occur in the progression to invasive cancer. This has been observed for cathepsin D (Zhao et… Angiogenesis of Early Breast Lesions • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 Angiogenesis is known to be important in metastasis, and microvasculature density, defined as vessels per unit area, has been reported to be a reliable prognostic indicator in early stage breast cancer (Weidner… Orthotopic Tissue Interactions • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 Most of what is known about the role of mammary tissue interactions in progression is based on studies with preneoplastic mouse mammary tissues. These lesions require normal mammary stroma for growth and progression to… Biology of High Risk Benign Breast Lesions - Introduction • Breast Cancer • • Biology of High Risk Benign Breast Lesions • Jun 12 08 The natural history of breast cancer indicates that it develops over years-even decades-and may progress through recognizable stages of proliferative breast disease. Although breast cancers are slow growing,… Screening for Breast Cancer - Conclusion • Breast Cancer • Jun 10 08 The decision to screen women for breast cancer is based on the importance of the disease as a public health problem and the demonstrated ability of screening tests to meet acceptable… Other Screening Tests • Breast Cancer • Jun 10 08 The search for alternative methods of screening for breast cancer is stimulated by a desire to increase accuracy and to overcome some of the technical barriers associated with film screen mammography. We do not… Quality Assurance • Breast Cancer • Jun 10 08 The usefulness of mammography is dependent on the proper use of dedicated mammography equipment, the diagnostic skills of the interpreter, and assessing and diminishing barriers to its regular use. These issues have been and are… Guidelines and Risk-Based Screening • Breast Cancer • Jun 10 08 By convention, in the United States, most guidelines for breast cancer screening recommend that women begin screening at age 40 or at some time in their 40s. Guidelines that recommend screening beginning at… Sensitivity, Specificity, and Positive Predictive Value • Breast Cancer • Jun 10 08 The interpretation of a screening examination ultimately falls into one of two categories: normal or abnormal. These judgments, in turn, ultimately are divided among four categories based on either the determination… Mammography Trials and Meta-Analyses • Breast Cancer • Jun 10 08 Following are brief summaries of the major randomized trials of breast cancer screening. They represent study designs in which a large group of women was randomly assigned to a group that either would… Evaluation of Breast Cancer Screening • Breast Cancer • Jun 10 08 Evaluation of Breast Cancer Screening The efficacy of a screening test is best evaluated with a population-based, randomized clinical trial with a mortality end point. Randomized trials eliminate the potential biases… Disease Burden - Screening for Breast Cancer • Breast Cancer • Jun 10 08 Disease Burden By a sizable margin, breast cancer is the most common malignancy diagnosed in American women and the second leading cause of death from cancer. According to current… Principles of Cancer Screening • Breast Cancer • Jun 10 08 The decision to screen an asymptomatic population for preclinical disease is based on well-established, although not specific, criteria that relate to the disease in question and the characteristics of applicable screening test(s). The… Screening for Breast Cancer - Introduction • Breast Cancer • Jun 10 08 The importance of detecting localized breast cancer was recognized in the mid-eighteenth century by Henri Francois LeDran, who proposed that breast cancer originated as a localized disease that subsequently spread via… Page 5 of 7 pages « First < 3 4 5 6 7 > << Back to main
