Health news
Health news top Health news

   Login  |  Register    
Health News Make AMN Your Home PageDiscussion BoardsAdvanced Search ToolMedical RSS/XML News FeedHealth news
  You are here : > Health Centers > Cancer Health CenterVulvar Cancers

Paget’s Disease

Vulvar CancersNov 08, 2007

Paget’s disease is a rare intraepithelial disorder of the vulvar skin that is seen in postmenopausal women. Unlike VIN, the intraepithelial neoplastic cells are glandular rather than squamous. The lesion primarily occurs in whites of an average age of 65 years. Grossly, it appears as a reddish, eczematoid lesion. Microscopically, this type of lesion is characterized by large pale cells that often occur in nests and infiltrate the epithelium. Once the diagnosis is made, it is important to rule out the presence of an underlying cancer. A review by Lee and colleagues reported a total of 75 cases of Paget’s disease of the vulva: 16 (22%) of the patients had underlying invasive carcinoma of the adnexal structures and 7 (9%) had adnexal carcinoma in situ.

Paget’s disease of the vulva often spreads in an occult fashion, with margins extending beyond the normal appearance of the lesion.

If there is no evidence of an underlying malignant neoplasm, a wide local excision or total vulvectomy usually is performed. If a wide local excision is performed, a slightly deeper excision is needed to remove the epidermis down to the level of the underlying fat to ensure removal of adnexal skin structures. Because this lesion extends subepithelially, a frozen section in the operating room may assist in ensuring complete removal.

Bergen and colleagues evaluated 14 patients with Paget’s disease of the vulva that was treated by vulvectomy, skinning vulvectomy with a graft, or hemivulvectomy. With a median follow-up of 50 months, all patients were free of disease; however, three patients had had locally recurrent disease.

Other modalities (topical 5-FU cream, laser) have not been used for treatment of this disease. Because both local and distant recurrence is a major risk, close follow-up is required.

Provided by ArmMed Media

Email this to a friend Bookmark this! Printable Version


We are pleased to let readers post comments about an article. Please increase the credibility of your post by including your full name and email.

All comments are reviewed by our editors before they are posted on the site. Just keep it clean, kids. Commenting is not available in this weblog entry.

   [advanced search]   
Interactive Quiz:
1. An infant who sits with only minimal support, attempts to attain a toy beyond reach, and rolls over from the supine to the prone position, but does not have a pincer grasp, is at a developmental level of
2 months
4 months
6 months
9 months
1 year

Health Centers

  Head and Neck Cancer

  Esophageal Cancer

  Benign Esophageal Tumors

  Cancer of the larynx

  Salivary Gland Tumors

  Cancer of the Hypopharynx

  Cancer of the Oropharynx

  Cancer of the Oral Cavity

  Cancer of the Nasal Cavity

  Head and Neck Cancer
      (- for profesionals -)

  Gynecologic cancers

  Cervical cancer

  Endometrial Cancer

  Fallopian Tube Cancer

  Ovarian Cancer

  Vaginal cancer

  Vulvar Cancer

  Ureteral & Renal Pelvic

  Uterine Cancer

  Gestational Trophoblastic

  Bladder cancer

  Breast cancer

  Colorectal Cancer

  Carcinoma of the Anus

  Anal Cancer Management

  Hodgkin's lymphoma

  Kaposi's sarcoma

  Kidney cancer

  Laryngeal cancer

  Liver cancer

  Lung cancer

  Lung cancer non small cell

  Lung cancer - small cell

  Oral cancer


  Cancer of the Penis

  Prostate cancer

  Skin cancer

  Stomach cancer

  Testicular cancer

» » »

Health Centers


Health news

Health Encyclopedia

Diseases & Conditions

Drugs & Medications

Health Tools

Health Tools

   Health newsletter


   Medical Links

   RSS/XML News Feed


Add to Google Reader or Homepage
Cancer: Overview, Causes, Risk Factors, Treatment
Add to My AOL