Table 118-4) is based on the findings at surgical exploration. A preoperative evaluation should exclude the presence of extraperitoneal metastases. A thorough surgical exploration is important because subsequent treatment will be determined by the stage of disease. In patients whose exploratory laparotomy does not reveal any macroscopic evidence of disease by inspection and palpation of the entire intraabdominal space, a careful search for microscopic spread must be undertaken. In an earlier series in which patients did not undergo careful surgical staging, the overall 5-year survival for patients with apparent stage I epithelial ovarian cancer was only about 60%. Survival rates of 90% to 100% have been reported for properly staged patients found to have stage IA or IB disease.
Metastases in apparent stage I or II epithelial ovarian cancer are common. About 30% of patients whose ovarian epithelial cancers appear to be confined to the pelvis have occult metastatic disease in the upper abdomen or in the retroperitoneal lymph nodes. The importance of a comprehensive initial surgical staging is emphasized by the findings of a cooperative national study in which 100 patients with apparent stage I or II disease who were referred for subsequent therapy underwent additional surgical staging. In this series, 28% of patients initially thought to have stage I disease were upstaged, and 43% of patients thought to have stage II disease had more advanced disease. Thus, 31% of patients were upstaged as a result of additional surgery, and 77% were reclassified as stage III. Histologic grade was a significant predictor of occult metastasis, that is, 16% of patients with grade 1 lesions were upstaged, compared to 34% with grade 2 and to 46% with grade 3 disease.
Although the literature has emphasized the importance of thorough surgical exploration in patients with disease apparently localized to the ovaries, scant recognition is made of the semantic difficulty presented by the concept of extension to other pelvic (ie, stage II) or abdominal (ie, stage III) organs. No problem exists when the surgeon encounters discrete implants, or seeds, separate from the primary tumor, or when solid tumor is found growing into adjacent structures. A more common situation, however, is the apparently benign adherence of the tumor to adjacent structures in the absence of metastatic implants or obvious direct tumor extension. There is a considerable body of evidence that such benign adherence, when it is dense, is associated with a relapse risk equivalent to stage II, and that these patients should not be included in stage I, but rather in stage II. Adherence is considered dense when sharp dissection is required to mobilize the tumor, when a raw area is left at the site of adherence, or when cyst rupture results from dissecting free the adhesions. It is the practice at most North American centers to advance the stage of densely adherent tumors to stage II, and this was done in a recent multicenter study of stage I and II disease.
- Epithelial Ovarian Cancer
- Etiology and Epidemiology
- Genetic Risk for Epithelial Ovarian Cancer
- Biology and Prognosis of Ovarian Neoplasms
- Classification and Pathology
- Patterns of Spread
- Clinical Features
- Staging of Ovarian Cancer
- Treatment of Early Stage Ovarian Cancer
- Treatment of Advanced Stage Epithelial Ovarian Cancer
- Assessment of Response in Patients who are Clinically free of Disease
- Survival of Patients with Advanced Ovarian Cancer
- Nonepithelial Ovarian Cancer
After a comprehensive staging laparotomy, only a minority of women have local or regional disease (FIGO stages I and II). Of the 26,600 women diagnosed yearly with epithelial ovarian cancer in the United States, approximately 2,000 to 3,000 have the disease confined to pelvic structures. The prognosis for these patients depends on clinical-pathologic features, as summarized below.
Although accounting for only 15% to 20% of all cases, approximately one third to one half of all cured patients are derived from stage I, highlighting its importance. An indepth understanding of the management of stage I is hampered by the small fraction of patients with limited disease, as well as by their excellent long-term prognosis (over an 80% 5-year relapse-free rate). Consequently, Phase III randomized trials are difficult to conduct with this group due to their small numbers and low rate of recurrence and death. No controlled study to date has been able to establish a curative advantage to postoperative adjuvant therapy.
The most recent FIGO staging classification of stage I is, in practice, descriptive rather than prognostic. The classification recognizes nine subcategories of stage I. Subclasses A (unilateral), B (bilateral), and C (capsular penetration, tumor spillage, or positive peritoneal cytology) are each further subdivided according to differentiation into three grades.
Within each grade, it is incorrect to assume that the factors which assign patients to substages B and C necessarily carry a worse prognosis than substage A, or that rupture, capsular penetration, and positive peritoneal cytology all worsen prognosis to the same degree, or that ascites in the absence of positive cytology is not prognostic. Indeed, several studies have failed to show that bilaterality or iatrogenic intraoperative rupture had any influence on outcome. Data on the prognostic significance of positive peritoneal cytology in ovarian cancer are scarce and inadequate.
Revision date: July 5, 2011
Last revised: by Janet A. Staessen, MD, PhD