Malignant Lymphomas

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The malignant lymphomas are a group of lymphoproliferative disorders that are usually divided into Hodgkin’s disease and the non-Hodgkin’s lymphomas. These two disease entities have markedly different clinical characteristics. For instance, Hodgkin’s lymphomas commonly occur as localized areas of lymph node enlargement. They tend to spread to contiguous lymph node groups and do not commonly involve extranodal sites of disease. Further, they are cured in more than 75% of the cases. Non-Hodgkin’s lymphomas tend to be disseminated at presentation, will spread in a discontinuous fashion, and frequently involve extranodal areas. Further, the cure rates remain in the 30% to 40% range. The cell of origin in the non-Hodgkin’s lymphomas is usually a B cell but occasionally a T cell. The cell of origin in Hodgkin’s disease remains unknown.

An experienced hematopathologist is required to distinguish some forms of non-Hodgkin’s lymphoma from Hodgkin’s disease. However, the importance of the subclassification of the non-Hodgkin’s lymphomas is critical, as is detailed later.

RELATED STORIES:
Monoclonal Gammopathy of Uncertain Significance   Essential Thrombocythemia   Multiple Myeloma   Myelodysplasia   Chronic Myelogenous Leukemia   Hairy Cell Leukemia   Plasma Cell Dyscrasias   Myeloproliferative Disorders   Amyloidosis   Myeloid Metaplasia with Myelofibrosis (MMMF)   Acute Leukemias   Waldenstrom’s Macroglobulinemia   Hodgkin’s Disease   Chronic Lymphocytic Leukemia   Polycythemia Vera   Non-Hodgkin’s Lymphomas

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