Link Uncovered Between Benign Prostatic Hyperplasia, NSAIDs

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Men with slow urine flow from enlargement of the prostate gland (known as benign prostatic hyperplasia or BPH) should avoid anything that makes the situation worse - and that includes some medications. The most common offenders are over-the-counter cold and allergy remedies. Now, some research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, may also affect the prostate’s function, reports the September 2007 issue of Harvard Men’s Health Watch.

Researchers in the Netherlands found that the risk of acute urinary retention (severe difficulty urinating) was twice as high in men taking NSAIDs as in men who were not using them. 

By contrast, though, researchers in America evaluating the long-term effects of NSAIDs on the prostate found that daily NSAID use was linked to a reduced risk of developing BPH symptoms and slow urinary flow rates.

At first glance the studies seem contradictory, but a closer look suggests that NSAIDs may be both friend and foe, depending on the stage of BPH and the part of the urinary tract that’s vulnerable.

The American study evaluated the onset of BPH symptoms. There is emerging evidence that inflammation may play a role in development of BPH. If that’s the case, regular NSAID use might delay the onset of symptoms. The Dutch study, which evaluated established cases of acute urinary retention, found that men who had recently begun taking NSAIDs were at the highest risk. These men may already have been developing BPH for years before taking the NSAIDs. And the NSAIDs may have caused trouble by acting on the bladder, not the prostate.

Harvard Men’s Health Watch suggests that if men notice an increase in BPH symptoms while taking an NSAID, they should inform their doctors and reduce or avoid NSAIDs.

Also in this issue:
• How to increase “good” cholesterol
• Help for restless legs syndrome
• MRIs and stents: Incompatible?

Harvard Men’s Health Watch is available from Harvard Health Publications, the publishing division of Harvard Medical School, for $24 per year.

Source: Harvard Men’s Health Watch

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