Jefferson researchers identify critical marker of response to gemcitabine in pancreatic cancer

	Tweet

A protein related to aggressive cancers can actually improve the efficacy of gemcitabine at treating pancreatic cancer, according to a Priority Report in Cancer Research, published by researchers at Thomas Jefferson University.

The protein, called Hu antigen R (HuR), is a stress response protein found in the cytoplasm of pancreatic tumor cells. In certain experimental settings, pancreatic cancer cells that overexpressed HuR were up to 30-fold more sensitive to gemcitabine (Gemzar), according to Jonathan Brody, Ph.D., assistant professor of Surgery at Jefferson Medical College of Thomas Jefferson University.

In a clinical correlate study that included 32 resected pancreatic cancer patients who received gemcitabine, patients who had low cytoplasmic HuR levels had a 7-fold increased mortality risk compared to patients with high levels. This was after adjustment for other variables including age, sex, radiation therapy and other chemotherapy use.

"This marker appears to tell us upfront whether a patient will respond to treatment with gemcitabine, which is the routine treatment for pancreatic cancer,” said Dr. Brody, who is the senior author of the study. “Of course, larger and comprehensive prospective studies need to be performed, but we now have a real clue about how to make this treatment better. Finding a mechanism that regulates gemcitabine’s metabolism in pancreatic cancer cells is the real novel and exciting aspect of these findings.”

Dr. Brody and colleagues found that in pancreatic cancer, HuR helps to regulate an enzyme called deoxycytidine kinase (dCK), which is responsible for metabolizing and activating gemcitabine. As with most chemotherapy drugs, gemcitabine causes cell stress and activates the HuR stress proteins. In turn, the high levels of HuR stimulate the production of more dCK, thus making gemcitabine more efficient, according to Dr. Brody.

“Normally, patients higher HuR cytoplasmic levels have a worse prognosis, since HuR expression is associated with advanced malignancies,” Dr. Brody said. “However, in our study, they did better than patients with low HuR levels when they were treated with gemcitabine. We think it’s because they already have high HuR levels at the time of treatment, which may be a response to the tumor cell environment.”

According to Dr. Brody, research is underway to find a way to activate HuR in patients with a low expression. Other goals include expanding these findings to a larger pancreatic cancer population, and to other tumors that may be treated with gemcitabine, including breast, ovarian and certain lung cancers. They also want to determine if other chemotherapeutic agents engage this intriguing and manipulative pathway.

###

Co-authors of the paper include Charles J. Yeo, M.D., Samuel D. Gross Professor and chairman of the department of Surgery, and Agnieszka Witkiewicz, M.D., assistant professor of Pathology, Anatomy and Cell Biology. Drs. Brody, Yeo and Witkiewicz are co-directors of the Jefferson Pancreas, Biliary and Related Cancer Center.

Other study collaborators include Dr. Myriam Gorospe from the National Institute on Aging (NIH) and Dr. Judith Keen from the University of Medicine and Dentistry of New Jersey.

Contact: Emily Shafer

215-955-5291
Thomas Jefferson University

RELATED STORIES:
EGFR essential for the development of pancreatic cancer   Researchers Find Gene Therapy that Kills Pancreatic Cancer Cells   Preoperative/neoadjuvant therapy in pancreatic cancer   Gene Discovered by Researchers Tied to Pancreatic Cancer   Johns Hopkins Scientists Crack Genetic Code for Form of Pancreatic Cancer   Pancreatic Cancer Expert at University of Virginia   Fizzy drinks increase risk of pancreatic cancer   Popular herbal supplement hinders the growth of pancreatic cancer cells   Metastasis of pancreatic cancer in action   Pancreatic Cancer Patients Have Elevated Fructose Levels New Test May Help in Understanding the Health Effects of High Fructose Intake   Burned meat linked to pancreatic cancer   A tumor of the pancreas mimicked by colonic duplication?   Drug slows prostate tumor growth by keeping vitamin A active   Possible Genetic Link to Pancreatic Cancer   Researchers ID Gene Involved in Pancreatic Cancer   New molecular therapy candidates for pancreatic cancer   Tests may detect mesothelioma, pancreatic cancer   Micro Molecules Can Identify Pancreatic Cancer   First Use of Innovative “IRE” on Pancreatic Tumor   Mayo Clinic Researchers Find Oncogene is Important in Pancreatic Cancer Growth and Spread   Alcohol Consumption May Increase Pancreatic Cancer Risk   New treatment combination safe for pancreatic cancer patients

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]