Cancer drug Gleevec may damage heart: study

	Tweet

Gleevec, the pill that transformed the treatment of a difficult type of leukemia by targeting the underlying defect, may cause serious heart damage, researchers cautioned on Sunday.

They found evidence that treatment caused heart failure in 10 patients who took Gleevec (called Glivec in some countries), made by Swiss drugmaker Novartis.

Patients should not stop taking the drug, known generically as imatinib, but should be watched closely for heart damage, the team at Jefferson Medical College in Philadelphia, Tufts University School of Medicine in Boston, University of Texas and elsewhere said.

Other drugs in the same class, tyrosine kinase inhibitors, may also damage the heart, the researchers report in the August issue of the journal Nature Medicine.

“Gleevec is a wonderful drug and patients with these diseases need to be on it,” Thomas Force, who led the study, said in a statement.

“We’re trying to call attention to the fact that Gleevec and other similar drugs coming along could have significant side effects on the heart and clinicians need to be aware of this. It’s a potential problem because the number of targeted agents is growing rapidly.”

When Gleevec hit the market in 2001, it made headlines because it stopped a difficult type of cancer, chronic myelogenous leukemia or CML, in most patients. Studies show it keeps anywhere between 80 and 90 percent of CML patients cancer-free for at least five years.

Usually half of the 4,600 new CML patients diagnosed each year die.

Gleevec is also approved for gastrointestinal stromal tumors or GIST, a rare type of stomach cancer.

It stops the activity of a protein called Bcr-Abl, which causes the out-of-control behavior of white blood cells in CML.

WATCHING PATIENTS

Force’s team studied the 10 human patients, who developed heart failure while taking Gleevec at M.D. Anderson Cancer Center in Houston. They then tested the drug in lab dishes and in mice. It appears to be toxic to cardiac cells, they said.

Mice treated with Gleevec developed left ventricular dysfunction, one of the key symptoms of heart failure in which the heart fails to pump out blood completely.

Patients taking Gleevec should be followed closely for symptoms of heart trouble, Force’s team advised.

“While the cancer is treated effectively, there will be some percentage of patients who could experience significant left ventricular dysfunction and even heart failure from this,” Force said in a statement.

Heart failure is a serious and chronic condition that itself kills up to half of patients within five years.

Novartis said the cases of heart failure in Gleevec patients were extremely rare and said those few patients were successfully treated with two drugs that can help heart failure—ACE inhibitors and carvedilol.

“Further study is necessary to better understand the relationship between these preclinical studies and their potential impact on the clinical management of patients taking Glivec,” the company said in a statement.

Drug companies are working on several “second-generation” Gleevec-type drugs, and they could also cause the problem, Force said.

“The drugs are all tyrosine kinase inhibitors, but each tyrosine kinase is different,” Force said. “It’s difficult to predict what tyrosine kinases will have protective roles in the heart and inhibition of them will be toxic.”

RELATED STORIES:
Doctors Hesitate to Discuss Fertility Preservation With Cancer Patients   Late-Breaking Science and Clinical Trials   Tumor mechanism identified   Acupuncture, massage helpful after cancer surgery   Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers   Cancer-causing gene discovery suggests new therapies   Einstein Receives High-Risk/High-Reward Cancer Research Funding   Metastasis formation revealed in detail and real time   Mechanism for invasion of tumorous cells discovered by Hebrew University researchers   Cannabis ingredient can help cancer patients regain their appetites and sense of taste   Scientist Finds First Evidence Of Alcohol-Cancer Link   GW wins US okay for pivotal cannabis drug study   New Hybrid virus may aid treatment of cancer   Blocking common gateway to inflammation suppresses cancer   Drug combo boosts Pancreatic cancer survival - study   Life Lessons on Cancer Risk for Children Whose Parent Has Genetic Mutation   Study finds way to predict when cancer will spread   Cancer patient jailed for threats   Tobacco cause of most cancers in black men   Cancer costs highest for individually insured   Keeping at-risk cells from developing cancer   New Markers of Prognosis for Cancer Therapies Highlighted

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]