Emerging research heralds new era of breast cancer management

	Tweet

Aggressive research currently underway brings hope of dramatic advances in breast cancer management, according to a new review. Published in the March 15, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the review reveals that new approaches in breast cancer imaging, investigations into the timing of chemotherapy, and research on breast cancer vaccines may lead to exciting new nonsurgical tools for the physician treating breast cancer patients. These new tools may significantly alter current screening and treatment paradigms used by surgical oncologists, as well improving the care of patients.

Our understanding of breast cancer has changed since Dr. William Halsted started performing radical mastectomies in the 1880s. Advances in genetics, immunology, and cell biology have demonstrated that breast cancer is not a single disease, but a complex family of diseases that requires fine-tuning of treatment at the level of the each individual patient. The current multidisciplinary approach to breast cancer treatment - surgery, radiotherapy, chemotherapy, hormonal therapy, targeted therapy-will continue to evolve as our knowledge of the disease grows. 

S. Eva Singletary, M.D., F.A.C.S, a surgeon from the University of Texas M. D. Anderson Cancer Center in Houston, discusses the latest research in breast cancer screening and management in this new review. “As we progress into the 21st century,” she writes, “new treatment schema and devices outside of the surgical arena may significantly alter” current practices.

She finds that current research in the fields of radiology, drug therapeutics, and vaccine development has great potential to change breast cancer management. In radiology, 3-dimensional digital mammography, color doppler ultrasonography, and other more sophisticated technologies, such as magnetic resonance imaging (MRI), are being refined to more accurately identify the size and location of tumors, and to distinguish between benign and malignant lesions. The use of nanotechnology may provide safer imaging that capitalizes on our growing knowledge of specific genes associated with cancer.

In the area of systemic therapy, the timing of drug treatments is being altered to maximize cell death, “short-circuit” tumor growth, and minimize toxicity to the patient. Though early in development, vaccines that stimulate the patient’s own immune system to attack developing tumors are being tested in animals with encouraging results. Preliminary clinical trials in breast cancer patients have also shown promising immune responses, although much remains to be done in this complex, but promising, area of research.

“During the lifetime of most surgeons practicing today,” Dr. Singletary writes, “we have seen breast cancer management evolve dramatically from a paradigm centered on radical surgery to one that involves the synergistic combination of multidisciplinary approaches.” She concludes, “It will be important for surgeons to stay aware of all developments that may improve the care of their patients, and to be true surgical oncologists rather than merely surgical technicians.”

###

Article: “Multidisciplinary Frontiers in Breast Cancer Management: A Surgeon’s Perspective,” S. Eva Singletary, CANCER; Published Online: February 12, 2007 (DOI: 10.1002/cncr.22519); Print Issue Date: March 15, 2007.

John Wiley & Sons, Inc.

RELATED STORIES:
Radiation After Mastectomy Underused   New role discovered for breast cancer susceptibility gene BRCA1   Fish oil may cut breast cancer risk ‘by a third’   Discovery halts breast cancer stem cells   Exercise, green tea may lessen breast cancer blues   3-week radiation therapy as effective as 5 weeks for early-stage breast cancer   Not all breast cancers’ risk are increased by Hormone Replacement Therapy   Breast reduction surgery may uncover cancer risk   Omega-3 fats tied to less cancer-related fatigue: study   Seven quality guidelines for breast, colorectal cancer care   Breast Cancer Is 10 Diseases Says Landmark Study   Diabetes drug shows promise in reducing risk of cancer   IMRT reduces risk of side effects in breast cancer patients   Weight Gain/Risk of Breast Cancer in Postmenopausal Women   RI Hospital first in country to enroll patient in new study for recurrent chest wall breast cancer   Big Bias In Who Gets Screened for Breast Cancer   Anti-estrogen Drug Therapy Reduces Risk of Invasive Breast Cancer in Older Women   Princeton scientists discover mechanism involved in breast cancer’s spread to bone   Researchers Finding New Ways to Prevent, Diagnose and Treat Breast Cancer   Potential New “Twist” in Breast Cancer Detection   Breast Cancer Brachytherapy May Be Overused   Experts question motives of mammogram guidelines

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]