Three variants of one gene thought to be involved in DNA repair were linked to a higher likelihood of reporting poor quality of life overall. Variations in some other genes associated with metabolism and pain were linked to higher or lower risks of fatigue, or a lower risk of pain.

Sloan said that researchers are continuing to study the role of genes in quality of life.

“We don’t expect to find a ‘quality-of-life gene,’” Sloan said. “It’s more complicated than that.”

But he did say he can envision a future where testing cancer patients for certain gene variations could help spot those who might “have a rougher ride” through treatment.

Doctors may be able to accomplish that just by asking about quality of life, Sloan acknowledged. But, he added, it could turn out that a combination of old-fashioned talking and genetic tests works best for figuring out who’s most vulnerable.

SOURCES: Journal of Clinical Oncology, online March 26, 2012.

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Relationship Between Deficits in Overall Quality of Life and Non–Small-Cell Lung Cancer Survival

  Jeff A. Sloan,
  Xinghua Zhao,
  Paul J. Novotny,
  Jason Wampfler,
  Yolanda Garces,
  Matthew M. Clark and
  Ping Yang