Colorectal Cancer More Common Among Diabetics

There’s more evidence that people with Diabetes have a significantly higher risk of developing Colorectal cancer, investigators reported here.

In a cross-sectional analysis of 226,953 participants who participated in the National Health Interview Survey (NHIS) during 1997 to 2003, 13,399 (5.9%) reported a history of Diabetes, according to Donald Garrow, M.D., of the Medical University of South Carolina in Charleston and colleagues.

After controlling by multiple logistic regression for obesity, gender, race, and smoking status—all associated with both Diabetes and Colorectal cancer—respondents with Diabetes were significantly more likely to develop Colorectal cancer (OR = 1.39, 95% CI = 1.15-1.67), they reported at the American College of Gastroenterology meeting here.

Among the respondents, the rate of Colorectal cancer among those with Diabetes was 1.39%. For those without Diabetes, the rate was 0.47%.

Additionally, in vitro studies had shown that hyperinsulinemia and hyperglycemia promote the growth of Colorectal cancer, and that both insulin and insulin-like growth factor-1 (IGF-1) receptors had been associated with such malignancies. Further, high levels of circulating IGF-1 had been linked to both certain benign polyps and to cancer, he added.

Not surprisingly, people who were older than 50 were nearly 14 more times as likely to get Colorectal cancer. However, white respondents were 40% more likely to get Colorectal cancer, and obese respondents had a slightly lower risk, approximately 20%. Smoking and alcohol use were also associated with a slight elevation in risk, 43% and 10% respectively.

On the basis of these studies the investigators did not put diabetics into a high-risk category for aggressive screening. “Caution should be taken with interpretation of this analysis, given the cross-sectional nature of this design,” they said.

Source: American Journal of Gastroenterology

RELATED STORIES:
Study Sets Treatment Standard for Elderly with Colon Cancer   Colonoscopy used to identify and remove flat colon lesions   Targeted Therapies Showing Great Promise Against Colorectal Cancer   Researchers Find Possible Link Between Bacterium and Colon Cancer   Aspirin Or NSAIDs Won’t Prevent Colorectal Cancer   CT scans may predict survival in colorectal cancer   Fish oil linked to increased risk of colon cancer in mice   Stool Testing Novel Technique for Detecting Colon Cancer   PET scans lead to treatment changes in majority of colorectal cancer patients   Use of Low-Dose Aspirin Associated with Improved Performance of Test for Detecting Colorectal Cancer   Colorectal cancer survival advantage in MUTYH-associated polyposis   Glaxo HPV vaccine protects women from anal cancer: study   Lower socioeconomic status decreases chances of early detection and survival of colorectal cancer   New bowel cancer evidence calls for routine DNA repair test   Minimally Invasive Surgery Shown Safe and Effective Treatment for Rectal Cancer   Cigarette smoking increases colorectal cancer risk   Balancing oxaliplatin dose with neurological side effects in metastatic colon cancer   Healthy life could prevent 23 percent of colon cancers   Does sex matter in colon cancer screening?   Regular, long-term aspirin use reduces risk of colorectal cancer   Colon Cancer Linked to Lineage   Hour of daily exercise cuts bowel cancer risk

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]