The sequencing of the human genome has opened the door for proteomics by providing a sequence-based framework for mining proteomes. As a result, there is intense interest in applying proteomics to foster a better understanding of cancer processes, develop new biomarkers for diagnosis and early detection of cancer. Gastric carcinoma is one of the most common malignancies worldwide and is the most common cause of cancer-related death in China. The main barrier for improving survival rate is short of useful marker for early diagnosis.
A research article to be published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Liu from Ruijin Hospital of China isolated and identified differentially expressed proteins between cancer and normal tissues of gastric cancer by 2-DE and MALDI-TOF-MS.
Total proteins were isolated from tumor and normal tissues and then separated by 2-DE. Differentially expressed proteins were isolated and identified by MALDI-TOF or MALDI-TOF-TOF-MS. Twenty three differentially expressed proteins were found between tumor and normal tissues of gastric cancer, among these fifteen proteins were identified. These differential proteins will be candidate markers for gastric cancer. It may be useful for diagnosis, treatment target and prognosis.
Li W, Li JF, Qu Y, Chen XH, Qin JM, Gu QL, Yan M, Zhu ZG, Liu BY. Comparative proteomics analysis of human gastric cancer. World J Gastroenterol 2008; 14(37)- 5657-5664
About World Journal of Gastroenterology
World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF- 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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World Journal of Gastroenterology