New DNA technique leads to a breakthrough in child cancer research

	Tweet

Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden and Karolinska Institutet have used novel technology to reveal the different genetic patterns of neuroblastoma, an aggressive form of childhood cancer. This discovery may lead to significant advances in the treatment of this malignant disease, which mainly affects small children.

The article is being published in the respected scientific journal, Proceedings of the National Academy of Sciences (PNAS). The study includes 165 children with neuroblastoma, most of whom developed the disease before the age of five. These children have been monitored for over 20 years by two research teams led by professors Tommy Martinsson, of the Sahlgrenska Academy, and Per Kogner of Karolinska Institutet.

Neuroblastoma is a nerve cell cancer that has defects in certain chromosomes. If the tumour has a characteristic defect on chromosome 11, it is very aggressive and difficult to cure. 

"We found that the children who develop this type of neuroblastoma are twice as old at the onset of the disease as children who develop other types of neuroblastoma. This type progresses more slowly and is more difficult to treat,” says Helena Carén, a researcher at the Department of Clinical Genetics at the Sahlgrenska Academy.

By using the latest genetic techniques, the researchers have succeeded in analysing the DNA of tumour cells and identifying chromosomal defects, enabling the identification of sub-groups of the most aggressive neuroblastomas. The next step is to identify their weak points genetically in order to develop better treatment.

“We call this personalized medicine, because the treatment is based on the genetic profile of the patient, or in this case, of the tumour cells,” says Tommy Martinsson, professor of genetics at the Department of Clinical Genetics at the Sahlgrenska Academy.

Per Kogner, professor of paediatric oncology at Karolinska Institutet, reiterates that their discovery will now allow a variety of tailor-made treatments to be developed, saving the lives of more children.

“The analytical method we have used in our research is already being used for clinical assessment of every neuroblastoma tumour in the country, which means that we can now make more accurate diagnoses,” says Helena Carén.

###

The study was carried out with the support of the Swedish Childhood Cancer Foundation and the Swedish Cancer Society.

ABOUT NEUROBLASTOMA

Neuroblastoma is a form of cancer that affects small children, most of whom are diagnosed before they reach their fifth birthday. It is the third commonest form of cancer in children, after leukaemia and brain tumours. About 20 Swedish children are affected every year, and the risk of developing the disease is the same worldwide. Neuroblastoma is a tumour of nerve cells. It appears during the development phase of the sympathetic nervous system. Children may have no symptoms at all, and sometimes a lump is the first sign of the disease noticed by parents or doctors. As the tumour grows or spreads, it may press on other organs and cause symptoms. The available treatments include surgery, chemotherapy, radiotherapy, high-dose therapy combined with stem cell support, and vitamin A. 

RELATED STORIES:
Focusing Patients on the “Can” in Cancer Diagnosis, Treatment, and Recovery   How to Prevent Radiation Mistakes in Cancer Patients   Farmers’ kids at risk for Ewing’s sarcoma   Cancer Prevention News Tips   Personalized medicine helps cancer patients survive   Cancer deaths across Europe ‘tipped to fall in 2011’   Scientists decode secrets of a very common virus that can cause cancer   Biochemist uses computer models to study protein involved with cancer, aging and chronic disease   Lung cancer tied to family risk of other cancers   Cancer Stem Cells: Know Thine Enemy   Study finds that tumor cells can prevent cancer spread   Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers   How Growing Older Affects Cancer Risk and Outcomes   NYU Langone scientists find key pathway implicated in progression of childhood cancer   Mobile phones don’t hike cancer risk: Danish study   How to recognize at an early stage whether a new cancer therapy prolongs life   Anti-cancer drugs based on platinum   Deleted Genes Help Predict Outcome in a Children’s Cancer   Low testosterone a problem in cancer: study   Cancer Mortality Rates Experience Steady Decline   New Study Begins for Kids With High-Risk Cancer   Study Identifies New Form of Inherited Risk of Cancer

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]