Some of the earliest randomized trials in all of clinical medicine, conducted in the 1950s, tested the use of radiation therapy (RT) in patients with invasive…

Breast cancer is one of the most prevalent malignancies among women in the western world. Well-designed scientific trials in the diagnosis and management of this disease remain paradigms for investigators in all fields.

Among the sites of systemic failure most prevalent in patients with breast cancer, brain and bone metastases are very adequately treated with brief courses of radiation. In certain circumstances, surgical excision of a…

Among patients who experience failure within the treated breast after breast-conservation therapy, mastectomy is the standard of care. When there has been a considerable disease-free interval between the treatment of the primary tumor…

Two important changes have occurred over the last decade in the definition of locally advanced breast cancer.  First, T3N0 lesions have now been categorized as Stage IIB disease, reflecting their…

NSABP-B04 demonstrated that radiation, in lieu of axillary dissection, for patients with clinical N0 or N1 breast cancer was adequate treatment and secured local control in the majority of patients.

Currently, most…

During the course of therapy, patients commonly experience erythema, irritation and tenderness of the treated breast. Occasionally, there is blistering in the inframammary and anterior axillary region. Our policy on skin care is…

Six randomized trials, both in the United States and Europe, demonstrated conclusively that lumpectomy followed by radiation therapy to the conserved breast tissue was as effective as modified radical mastectomy in…

Breast cancer was the first major malignancy demonstrated to be adequately treated with organ preservation. The impact of the randomized trials performed in the United States and Europe to investigate the effectiveness…