High-Grade Prostate Cancer Linked to Diabetes

	Tweet

Among obese white men, those with diabetes mellitus (DM) are more likely than non-diabetics to have high-grade prostate cancer discovered on prostate biopsy, according to researchers.

Investigators at Duke University Medical Center in Durham, N.C., studied 1,031 men undergoing their first prostate biopsy at the Durham VA Medical Center. Diabetes was present in 290 patients (28%) at the time of biopsy. A history of DM was associated with black race and higher BMI.

DM was not associated with prostate cancer risk overall, but in multivariate analysis, diabetes was significantly associated with a twofold increased risk of high-grade disease (Gleason score above 7). The association was stronger among obese men, in whom diabetes conferred a 3.76 times increased risk of high-grade disease. The researchers, led by Stephen J. Freedland, MD, observed no significantly increased risk among non-obese men.

After further stratification by race, DM was associated with high-grade disease only in obese white men, in whom diabetes increased the risk nearly fivefold. DM was not associated with the risk of low-grade disease in all men.

Researchers reported their findings at the American Urological Association annual meeting.

In a previous study published in Cancer Epidemiology, Biomarkers & Prevention (2010;19:9-17), Dr. Freedland and colleagues demonstrated that DM at the time of radical prostatectomy was associated with worse outcomes for obese white men, including a 2.5-fold increased risk of biochemical recurrence. Black men and non-obese white men had better outcomes.

“These two relatively independent findings both suggest race and obesity may modify the association between DM and aggressive prostate cancer,” said the study’s first author, Daniel M. Moreira, MD, a urological oncology fellow at Duke.

Dr. Freedland observed that “it is likely that a combination of biologic and behavioral factors may be responsible for our observed associations between DM and prostate cancer.”

---

Jody A. Charnow

RELATED STORIES:
Online tool supports more dialogue on prostate cancer risk   Prostate Tumor Hypoxia Predicts PCa Recurrence   Data Suggests a Diet High in Vegetable Intake Can Reduce Risk of Prostate Cancer   Few Side Effects from Radiation Treatment Given After Prostate Cancer Surgery   Prostate Cancer Grading & Staging   Lean body mass may protect against prostate cancer   ARRA Funds Research to Improve Prostate Cancer Identification   Untreated prostate cancer no death sentence   ‘Statins’ improve prostate cancer outcome   Many prostate cancers don’t need radical therapy   Rotating-shift work tied to prostate cancer risk   Beehive extract shows potential as prostate cancer treatment   Selected Men with Low-Risk Prostate Cancer Have Good Clinical Outcomes without Immediate Treatment   Predicting the Return of Prostate Cancer: New Study Betters the Odds of Success   Vitamin E may raise prostate cancer risk   Artificial Light at Night: Higher Risk of Prostate Cancer   Early prostate cancer detection, screening: No benefit for men with low baseline PSA value   Advanced-Stage Prostate Cancer Patients Experience 20-Year Survival Rates With Surgery   Surgical Prospectives in High-Risk Prostate Cancer   New gene test for prostate cancer at hand   Gleevec strangles drug-resistant, metastatic prostate cancer   Genetic factors key to prostate cancer death risk

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]