29% of Cancer Studies Report Conflict of Interest

	Tweet

Nearly one-third of cancer research published in high-impact journals disclosed a conflict of interest, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

The most frequent type of conflict was industry funding of the study, which was seen in 17 percent of papers. Twelve percent of papers had a study author who was an industry employee. Randomized trials with reported conflicts of interest were more likely to have positive findings.

“Given the frequency we observed for conflicts of interest and the fact that conflicts were associated with study outcomes, I would suggest that merely disclosing conflicts is probably not enough. It’s becoming increasingly clear that we need to look more at how we can disentangle cancer research from industry ties,” says study author Reshma Jagsi, M.D., D.Phil., assistant professor of radiation oncology at the U-M Medical School.

The researchers looked at 1,534 cancer research studies published in prominent journals. Results of this current study appear online in the journal Cancer.

“A serious concern is individuals with conflicts of interest will either consciously or unconsciously be biased in their analyses. As researchers, we have an obligation to treat the data objectively and in an unbiased fashion. There may be some relationships that compromise a researcher’s ability to do that,” Jagsi says.

For example, she says, researchers might design industry-funded studies in a way that’s more likely to produce favorable results. They might also be more likely to publish positive outcomes than negative outcomes.

“In light of these findings, we as a society may wish to rethink how we want our research efforts to be funded and directed. It has been very hard to secure research funding, especially in recent years, so it’s been only natural for researchers to turn to industry. If we wish to minimize the potential for bias, we need to increase other sources of support. Medical research is ultimately a common endeavor that benefits all of society, so it seems only appropriate that we should be funding it through general revenues rather than expecting the market to provide,” Jagsi says.

Methodology: The researchers looked at all original clinical cancer research published in five top oncology journals and three top general medical journals in 2006. The journals included were the New England Journal of Medicine, the Journal of the American Medical Association, Lancet, the Journal of Clinical Oncology, the Journal of the National Cancer Institute, Lancet Oncology, Clinical Cancer Research and Cancer.

Articles were analyzed to determine declared funding sources and conflicts of interest. A conflict of interest was identified if it was explicitly declared by the authors, if an author was an employee of industry at the time of publication, or if the study had industry funding.

Additional authors: Nathan Sheets; Aleksandra Jankovic, M.S.; Amy R. Motomura; Sudha Amarnath; and Peter A. Ubel, M.D.

Reference: Cancer, published online May 11, 2009; scheduled for print publication June 15, 2009

Resources:
U-M Cancer AnswerLine, 800-865-1125
U-M Comprehensive Cancer Center, http://www.mcancer.org
Source: University of Michigan Health System

RELATED STORIES:
Scientists identify a new gene that causes the spread of cancer   Smoking and hepatitis C up risk of lymphoma   Green tea may curb risk of some cancers   Medical costs of cancer have nearly doubled over the past 2 decades   PCB exposure may raise lymphoma risk   Discovery of a new mechanism of gene control that is associated with cancer   Cancer deaths continue to drop   Alcohol and Cancer: Know Your Limit   Jews who survived wartime Europe have more cancer   Rate of Secondary Cancers Increases Over Years After Treatment for Childhood Leukemia   Hereditary cancer risk   Cancer patient jailed for threats   Researchers Find New Path to Control Tumor Growth   UNC study supports role of circadian clock in response to chemotherapy   Inhaled morphine eases cancer-related air hunger   Repeat imaging in kids with cancer: a balancing act   Hodgkin Disease Survivors Face Higher Risk for Stroke Later in Life   Personalized medicine helps cancer patients survive   Cancer drug may fight smallpox, study suggests   Imaging Technology May Relieve Cancer Pain   Vitamin D Reduces Cancer Risk   Cancer: The good news

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]