Venous Thromboembolism

Nevertheless, some studies reported that the increase in activated protein resistance is greater with the patch than with either triphasic and monophasic COCs. (95). There are no sufficient data concerning vaginal rings.

In conclusion, epidemiological studies have indicated a risk 2-fold increased of nonfatal VTE with use of HCs containing desogestrel or gestodene compared with LNG.

Therefore,  these studies not provide evidence for a cause-and-effect relationship   between   HCs-  containing   desogestrel   or   gestodene   and   VTE.

Enhancement by thrombophilic diseases, especially with factor V Leiden mutation of risk of deep-vein-thrombosis associated with oral contraceptives containing a third –generation progestagen has been reported (62,66,82,90, 92). Until now, no sufficient and adequate data about the new formulations as patch, vaginal ring and combined hormonal contraceptives containing progestins with antiandrogenic properties were obtained.

Rosa Sabatini and Giuseppe Loverro
Dept. Obstetrics and Gynecology,
General Hospital Policlinico-University of Bari, Italy

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