The peliosis hepatis, firstly described in 1950 by Zak F.G., is a rare condition,sometimes fatal, characterized by areas of hepatocellular necrosis secondarily cystic,blood filled cavities of 1-3 mm of diameter in the parenchyma.
Initially,only focal hepatocellular necrosis may be present, sometimes hemorrhagic but in the severe and fatal cases, portal hypertension with varices and ascites, liver failure and/ or hemoperitoneum with shock secondary to intraperitoneal rupture were reported (1).
Some cases are reported in women taking oral contraceptives.In this circumstance, regression of the initial lesions is possible with termination of the etiologic agent (2,3).
This rare disease,generally develops in organs belonging to the mononuclear phagocytic system (liver,spleen, bone marrow,lymph nodes); however,a paucity of studies indicates that other organs such as lungs, parathyroid glands, and kidneys may be affected, too. (4)
Adverse Effects of Hormonal contraception
- Cardiovascular Effects
- - Myocardial Infarction
- - Stroke
- - Arterial Accidents
- - Venous Thromboembolism
- - Blood Hypertension
- Other Effects
- - Angioedema
- - Peliosis Hepatis
- - Severe Adverse Ocular Reactions
- - Vasculitis
- Moderate adverse effects
- Cancer Risks
- - Breast cancer risk
- - Ovarian cancer risk
- - Endometrial cancer risk
- - Cervical cancer risk
- - Colorectal cancer risk
- - Skin cancer risk
- - Liver cancer risk
- - Pancreatic cancer risk
- - Neurofibromas growth
- - Unclear cancer risks
- Hazardous prescription
- Hormonal contraception in female transplant recipients
- - Hormonal contraception in female kidney recipients
- - Hormonal contraception in female liver transplant recipients
- - Hormonal contraception in female heart transplant recipients
- - Contraception in women HIV infected
- Mild Adverse effects
- New Perspectives immunocontraception
- Contraceptive counseling
Rosa Sabatini and Giuseppe Loverro
Dept. Obstetrics and Gynecology,
General Hospital Policlinico-University of Bari, Italy
 Jacquemin, E., Pariente, D., Fabre, M., Huault, G.,Valayer, J., Bernard, O. (1999). Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children. J.Hepatol, 30(6), 1146-50.
 Hung, N.R.,Chantrain, L., Dechambre, S. (2004). eliosis hepatis revealed by biliary colic in a patient with oral contraceptive use. Acta Chir.Belg, 104(6), 727-9.
 Eugene, M., Chong, M.F., Genin, R., Amat, D. (1985). Peliosis hepatis and oral contraceptives :a case report. Mediterr. Med, 13(343), 21-24.
 Zafrani, E.S., Pinaudeau, Y., Le Cudonnec, B., Julien, M., Dhumeaux, D. (1980). Focal hemorrhagic necrosis of the liver.A clinicopathological entity possibly related to oral contraceptives. Gastroenterology, 79, 1295-9.