Liver cell adenomas are rare benign tumors whose incidence has been increasing since 1970 ⁽⁹¹⁾.

They generally occur in otherwise healthy women over age 30, who have used hormonal contraceptives (HCs)  for five years or longer ^(92,93).

In fact,evidence proved the link between the raise of incidence of hepatic adenomas and the widespread and prolonged use of the"pill”  ^{(94,95, 96)}.

Not rarely benign liver tumours are incidental findings on echography. Liver cell adenomas   are   not   premalignant   and may   undergo   reversible   change   after withdrawal of causative agents,such as oral contraceptives ^{(97,98,99 )}.

However, these tumors which regress when OC use stops,  can reoccur if HC use is reinstituted or if pregnancy occurs ^(94,100). 

The most extensive complication of hepatic adenoma is intratumoral or intraperitoneal hemorrhage,  which occurs in 50 to 60 per cent of patients ⁽¹⁰¹⁾.

The risk of developing adenoma is increased with duration of oral contraceptive use, and in larger tumors, the hemorrhagic risk is also increased in pill users ^(93,101).

Adenoma also occurs in people with Type Ia glycogen storage disease,and is associated with insulin dependent diabetes ⁽¹⁰¹⁾.

Some authors believe that liver cell adenomas are potentially premalignant and could degenerate into hepatocellular carcinoma but there is very few well documented reports of this transformation ^{(101,102,103 )}. Although a recent report shows that 10%  of hepatic adenoma progress to hepatocellular carcinoma ⁽¹⁰²⁾.