Colorectal cancer risk of Hormonal Contraception

This report   represents   the   regression   of   colorectal   adenomas   with   the   use   of estrogen/progesterone compounds   (74).

Ever users of oral contraceptives do not benefit from a long-term reduction in colorectal cancer,  although current and recent use may confer some protection.  Women who have used HRT appear to have important reductions in their risk of colorectal cancer, especially while using these hormones. 

Further study is needed in order to determine how long any benefits last and whether these are stronger in women exposed to both classes of exogenous hormones (75).


Rosa Sabatini and Giuseppe Loverro
Dept. Obstetrics and Gynecology,
General Hospital Policlinico-University of Bari, Italy


REFERENCES

  1.   La Vecchiam, C., Negri, E., Franceschi, S., Parazzini, F. (1993). Long-term impact of reproductive factors on cancer risk. Int J Cancer, Jan 21, 53(2), 215-9.
  2.   Medard,  M.L.,  Ostrowska, L.  (2007).Combined oral contraception and the risk of reproductive organs cancer in women .Ginekol Pol, Aug,78(8), 637-41. 
  3.   Casey, P.M., Cerhan, J.R., Pruthi, S. (2008). Oral contraceptive use and risk of breast cancer. Mayo Clin Proc,Jan,83),86-90
  4.   Deligeoroglou, E., Michailidis, E., Creatsas, G. (2003).Oral contraceptives and reproductive system cancer. Ann N Y Acad Sci,Nov,997,199-208.
  5.   White,  E.,  Malone,  K.E.,  Weiss,  N.S.,  Daling,  J.R.  (1994). Breast cancer among young US women in relation to oral contraceptive use.  J.  Nati Cancer Inst, 86(7), 505-14
  6.   Brohet,  R.M.,  Goldgar,  D.E.,  Easton,  D.F.,  Antoniou,  A.C.,  Andrieu,  N., Chang-Claude,  J.,  Peock,  S.,  Eeles,  R.A.,  Cook,  M.,  Chu,  C.,  Nogue`s,  C., Lasset,  C.,  Berthet,  P.,  Meijers-Heijboer,  H.,  Gerdes,  A.M.,  Olsson,  H., Caldes,  T.,  van Leeuwen,  F.E.,  Rookus,  M.A.  (2007). Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report   from   EMBRACE,  GENEPSO,  GEO-HEBON,  and   the   IBCCS Collaborating Group.J Clin Oncol, Sep 1,25(25), 3831-6.
  7.   Haile,  R.W., Thoma,  D.C.,  McGuire,  V.,  Felberg,  A.,  John,  E.M.,  Milne, R.L., Hopper, J.L. et.al. (2006). BRCA1 and BRCA2 mutation carriers, oral contraceptives use,and breast cancer before age 50. Cancer Epidemiol.Biomarker Prev, 15(10), 1863-70.
  8.   Daling, J.R., Brinton, L.A., Voigt, L.F., Weiss, N.S., Coates, R.J., Malone, K.E., Schoenberg, J.B., Gammon, M. (1996). Risk of breast cancer among white women following induced abortion. Am J Epidemiol, Aug 15,144(4), 373-80. 
  9.   Daling, J.R., Malone, K.E., Voigt, L.F., White, E., Weiss, N.S. (1997). Risk of breast cancer among young women:  relationship Med to induced abortion. N Engl J, 336(2), 81-5
  10.   Rookus,  M.A.,  van Leeuwen,  F.E.  (1996).Induced abortion and risk for breast cancer:  reporting (recall)  bias in a Dutch case-control study.  J Natl Cancer Inst, 88 (23),1759-64
  11.   Van   Leeuwen,  F.E.  (1991). Epidemiologic   aspects   of   exogenous progestagens in relation to their role in pathogenesis of human breast cancer. Acta Endocrinol, 125(1), 13.

Full References

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