The cases, published until now were almost fifty ;whereas, only nine known cases of progesterone-  induced anaphylaxis are reported until 2003₍₂₆₎. The diagnosis may be confirmed by performing a skin and/or intramuscular allergen test,  using   progesterone ₍₂₉₎.  These   cases   were   successfully   treated   with conjugated   estrogen, antiestrogen   tamoxifen,  danazol,gonadotropin   releasing hormone analogs or oophorectomy. Allergic contact dermatitis from contraceptive patch(estradiol   and   norethisterone   acetate)  and   local   and   systemic   contact dermatitis from estradiol had also been reported _(30,31). 

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Rosa Sabatini and Loverro Giuseppe
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