Delayed Puberty
Primary Amenorrhea with Developed Secondary Sex Characteristics
In cases of partially or completely developed secondary sexual characteristics, patients will refer to the physician for primary…
Hyperandrogenia
Sexual ambiguities have been diagnosed during the neonatal period.
However, pubertal development may be associated with…
Therapeutic Aspects
Treatment of delayed puberty and/or primary amenorrhea requires precise etiological diagnosis, determination of bone age and evaluation of…
Constitutional Delay in Growth and Puberty (CDGP)
Delayed puberty as described earlier has a statistical definition based on epidemiological studies. Onset of development, which includes…
Isolated Idiopathic IHH
Impaired Pulsatile Secretion of LHRH
In absence of anosmia, the Kal gene is not involved, as…
Congenital Gonadotropin Deficiency
Primary gonadotropin deficiency is associated with very low levels of FSH and LH, concordant bone age, normal stature…
Iatrogenic Ovarian Failure
Prepubertal girls treated with radiation therapy or chemotherapy may present gonadal failure with delayed puberty or primary or…
Non-Tumoral Acquired Organic Lesions of CNS
- Histiocytosis X (Hans-Schüller-Christian disease) is characterized by multiple organ infiltration (skin, bone, viscera) by histiocytic cells.…
Acquired IHH
Organic Direct Gonadotropin Deficiency
To establish etiological diagnosis, complete medical history and clinical exam are associated…
Karyotypically Normal 46,XX Ovarian Dysgenesis
Ovarian dysgenesis with a normal 46,XX karyotype is defined by reduced or altered ovaries, a female phenotype, and…
Delayed Puberty Clinical Aspects
Initial evaluation, based on a detailed history and complete clinical exam, will establish undeveloped, partially or completely developed…
Delayed Puberty Etiological Aspects
Actually, after this clinical exam and these simple complementary investigations, the physician often has a presumptive diagnosis. The…
Delayed Puberty Epidemiological Aspects
Age at onset of puberty varies greatly among individuals and populations and seems to be influenced by both…
Delayed Puberty Physiological Aspects
Increase in the pulsatile release of LHRH is a necessary condition for puberty onset, as demonstrated 22 years…
Delayed Puberty
Developmental changes during puberty in girls occur over a period of 3 - 5 years, usually between 9…
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