Precocious Puberty (Complete, Partial)
Precocious Puberty (Complete, Partial)
Department of Endocrinology, Great Ormond Street Hospital for Children and…
Gonadotrophin-Independent Precocious Puberty
GIPP occurs more commonly in boys (described as testotoxicosis) than in girls. However, when it does occur in…
Precocious Puberty
Precocious Puberty
There are many causes of precocious sexual development and these are probably best categorised…
Adrenal Dysfunction
Various adrenal disorders may cause premature sexual maturation.
However, this does not involve ‘gonadarche’ and so…
Central Precocious Puberty
Central Precocious Puberty
This is known as central, idiopathic or gonadotrophin-dependent precocious puberty. The pattern of…
Isolated Premature Thelarche
Isolated Premature Thelarche
Premature thelarche is a benign, self-limiting condition which is characterised by breast development…
Thelarche Variant
Thelarche Variant
This encompasses a spectrum of conditions, which lie between premature thelarche and central precocious…
Isolated Menarche
Isolated Menarche
This is a condition where young girls have cyclical uterine bleeding without any other…




