Menopause quality of life unchanged by soy supplements

Additionally, the researchers originally set out to look at the effects of soy extracts on bone health, and did not recruit women specifically with hot flash or quality of life concerns in mind.

“So in my opinion, no useful information about isoflavones and hot flashes is provided by this study,” said Messina, who regularly consults for companies that make or sell soy foods and supplements.

Isoflavone companies market the supplements, sold for about $17 for 90 50-mg pills, as “potentially” easing the changes associated with menopause.

What can soy offer women in menopause?

Soy and soy isoflavones have been closely studied and found supportive for a wide range of perimenopause and menopause symptoms and concerns: improved insulin regulation; weight loss; bone health; improved nail, skin and hair health; heart health; and decreased frequency and severity of menopausal discomforts, particularly hot flashes and night sweats.

In fact, beyond the three fundamentals embodied in our Personal Program - core nutrition, stress reduction, and botanical endocrine support - soy is our next-best-step when it comes to hot flashes in menopause. But that doesn’t mean it works for every woman - the underlying reasons for hot flashes and night sweats can differ in menopause, and about 20% of the population report they do not tolerate the protein from soy well.

For some women, soy can also have a positive impact on symptoms of PMS. Premenstrual problems can worsen for many women as they enter perimenopause and monthly hormonal cycles take on a more erratic pattern. PMS symptoms that may increase in perimenopause include irritability and other mood changes, breast tenderness, and headaches.

Though controversial, there are also some promising benefits for the aging brain to be weighed with soy. The effects of soy isoflavones observed on mood and cognitive performance in post-menopausal women have been positive - particularly with verbal memory - and this may be of relevance to younger women experiencing memory lapses and foggy thinking in perimenopause, too. We expect more studies will help us understand these effects better, but women with hormonal imbalance report these symptoms almost universally - no matter what their age.

Women who eat foods rich in soy protein are also doing their hearts a big favor. According to a comprehensive review of the literature by the FDA in the late 1990’s, eating 25 g of soy protein daily is enough to gain soy’s heart-healthy benefits. A study on post-menopausal women released in the fall of 2006 also showed reduced markers for inflammation linked to risk of cardiovascular problems, including homocysteine and C-reactive protein. As we enter menopause, minimizing any risk factors that jeopardize our heart health - including inflammation - will support our chances for longer, healthier lives.

Not only is soy high in protein (38% of the bean) but it’s also low in carbohydrates, making it a low glycemic index (GI) food that can support us in keeping our weight at a healthy level. Choosing foods with a low GI helps your blood sugar and insulin levels remain stable over time, helping you feel fuller longer, with fewer hunger cravings and fewer calories being stored as fat.

Amato agreed that the study has some limitations, and that the findings can’t be generalized to all forms of soy in all types of women.

For instance, “taking supplements just might not be the same as eating a high soy content diet your entire life,” she told Reuters Health.

Side effects/safety of soy

Studies abound on both the health benefits and the detrimental effects of soy, with somewhat conflicting results. Soy remains controversial - though as much as we’ve read about and used it at Women to Women, we’re not quite sure why soy seems to stir the passions of so many.

We’ve been following the soy controversy for years, and from what we see in the research and at the clinic, the preponderance of evidence falls clearly on the beneficial side - especially as a safe alternative to conventional HRT-based menopausal treatments.

When it comes to soy, we’ve also observed that it works extremely well for some women and moderately well for others, while there is that segment of the population that does not metabolize or tolerate it well, and a smaller subset that reacts adversely to it. This should come as no surprise to us, though, since we all know from personal experience that different body types often react differently to different foods - and after all, soy is a bean!

We will often suggest that women experiencing menopausal symptoms add whole, non-GMO soy foods to their diet to see how well they tolerate them. Most of our patients have done very well by it, some women thrive on it, and for one reason or another, a very few choose to avoid it entirely. We are excited to offer our own delicious SoySational supplement, designed to bring women relief from symptoms like hot flashes and night sweats that are associated with menopause. So whether you’re pre-, peri- or post-menopausal, we recommend you give soy a try and see for yourself.

But “if you look at this specific supplement for this particular group of women for this reason, quality of life, I’m convinced by this study it’s not terribly helpful,” she added.


SOURCE: Menopause, online December 3, 2012


Effect of soy isoflavone supplementation on menopausal quality of life

Objective: The purpose of this study was to assess the effect of soy isoflavone supplementation on quality of life in postmenopausal women.

Methods: A multicenter, randomized, double-blind, placebo-controlled 24-month trial was conducted to assess the effect of 80 or 120 mg of daily aglycone hypocotyl soy isoflavone supplementation on quality of life in 403 postmenopausal women using a validated Menopause-Specific Quality of Life questionnaire.

Results: Menopause-Specific Quality of Life domain scores at 1 year and 2 years were similar to baseline. There were no differences in domain scores among treatment groups.

Conclusions: Soy isoflavone supplementation offers no benefit to quality of life in postmenopausal women.

Amato, Paula MD; Young, Ronald L. MD; Steinberg, Francene M. PhD; Murray, Michael J. MD; Lewis, Richard D. PhD; Cramer, Margaret A. MD; Barnes, Stephen PhD; Ellis, Kenneth J. PhD; Shypailo, Roman J. BS; Fraley, Joe Kennard MPH; Konzelmann, Karen L. MS; Fischer, Joan G. PhD; LaSalle, Colette RD; Smith, Elliot O’Brian PhD; Wong, William W. PhD

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