Methapyrilene hydrochloride is an uncommon antihistamine found in cold or flu medicines. It is generally considered non-toxic in small doses, but higher doses or ingestion by a child can be extremely toxic.
- methapyrilene hydrochloride
- antihistamine medications (older)
- body as a whole o unsteadiness o tremor o Convulsions o difficulty urinating
- eyes, ears, nose, and throat o dilated pupils o vision abnormalities (blurry vision) o dry mouth
- skin o flushed skin (red) o dry skin
- heart and blood vessels o rapid heartbeat o Low Blood pressure
- nervous system o excitation o agitation o drowsiness o nervousness o hallucinations o disorientation o delirium o coma
Do not induce Vomiting. Seek emergency medical care immediately.
Before Calling Emergency
Determine the following information:
- the patient’s age, weight, and condition
- the name of the product (ingredients and strengths, if known)
- the time it was swallowed
- the amount swallowed
Poison Control, or a local emergency number
They will instruct you if it is necessary to take the person to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.
What to expect at the emergency room
Some, or all of the following procedures may be performed:
- for swallowed poison o Placement of a tube down the nose and into the stomach (a nasogastric tube, or an NG tube) to wash out the stomach. o Activated charcoal administration. o Take a blood sample taken to determine salicylate level in blood o Give IV fluids. o Admission to the hospital.
If the patient survives the first 24 hours, survival is likely. Few patients actually die from an antihistamine overdose.
by Martin A. Harms, M.D.