Definition 

Macroamylasemia is a condition in which macroamylase builds up in the blood.

Amylase is an enzyme that is filtered out of the blood by the kidneys. Macroamylase is a larger molecule consisting of amylase bound to a protein (an autoantibody). Unlike amylase, macroamylase is filtered very slowly from the blood by the kidneys. Having macroamylasemia causes an elevated amylase blood level reading.

Macroamylasemia has been associated with:

 
• Celiac disease  
• Ulcerative colitis  
• Rheumatoid Arthritis  
• lymphoma  
• HIV infection  
• monoclonal gammopathy

Approximately 1 percent of the population has macroamylasemia.

Medical Encyclopedia

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