Intrinsic factor

Definition 
Intrinisic factor is a protein, produced by glands in the stomach lining, which is necessary for intestinal absorption of vitamin B12.

A deficiency in intrinsic factor can cause pernicious anemia. Such deficiencies can be caused by surgical removal of the stomach, inherited conditions, or other diseases.

Johns Hopkins patient information

Last revised: December 4, 2012
by Amalia K. Gagarina, M.S., R.D.

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