Factor XII (Hageman factor) deficiency

Definition
This is an inherited disorder that causes prolonged clotting (coagulation) of blood in a test tube without a clinical bleeding tendency, and results from a deficiency of the plasma protein factor XII.

Causes, incidence, and risk factors
Factor XII deficiency is a hrare ereditary disorder that is usually found when clotting tests are done for routine screening. It is not associated with abnormal bleeding.

Symptoms
There are usually no symptoms.

Signs and tests

     
  • Prolonged partial thromboplastin time  
  • Abnormal factor XII assay

Treatment
Treatment is generally unnecessary.

Expectations (prognosis)
The outcome is expected to be good without treatment.

Complications
There are usually no complications.

Calling your health care provider
This condition is usually discovered by the health care provider when prolonged clotting is noticed in the process of running other laboratory tests.

Prevention
This is an inherited disorder. There is no known way to prevent it.

Johns Hopkins patient information

Last revised: December 8, 2012
by Brenda A. Kuper, M.D.

Medical Encyclopedia

  A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0-9

All ArmMed Media material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.