Alternative names 
Prochlorperazine overdose

Poisoning from an overdose of prochlorperazine.

Poisonous Ingredient


Where Found

  • Compazine


  • Body as a whole       o Dry mouth       o Hypothermia (body temperature is lower than normal)       o Incoordination       o Fever       o Tremor       o Inability to completely empty the bladder       o Weakness       o Difficulty swallowing       o Salivation       o Convulsions       o Stiff muscles in neck, face, or back       o Alteration of menstrual patterns       o Muscle spasms  
  • Eyes, ears, nose, and throat       o Nasal congestion       o Blurred vision       o Photosensitivity  
  • Skin       o Rash  
  • Gastrointestinal       o Nausea       o Constipation       o Loss of appetite  
  • Heart and blood vessels       o Low blood pressure (severe)       o Rapid heartbeat  
  • Nervous system       o Drowsiness       o Coma       o Disorientation

Home Treatment

Call Poison Control for instructions.

Before Calling Emergency
Determine the following information:

  • The patient’s age, weight, and condition  
  • The name of the product (ingredients and strengths if known)  
  • The time it was swallowed  
  • The amount swallowed  
  • If the medication was prescribed for the patient

Poison Control, or a local emergency number
They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room
Some or all of the following procedures may be performed.

  • Use gastric lavage.  
  • Administer activated charcoal.  
  • Administer a laxative.  
  • Replace fluid.  
  • Give an antidote.  
  • Treat the symptoms.

Expectations (prognosis)
Recovery depends on the nature and extent of the damage done. Survival past 2 weeks is usually a good sign.

Johns Hopkins patient information

Last revised: December 8, 2012
by Armen E. Martirosyan, M.D.

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All ArmMed Media material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.