Antihypertensives -Thiazide and related diuretics

Definition 
This is poisoning from a thiazide or related diuretic.

Poisonous Ingredient 
any of the following

     
  • bendroflumethiazide  
  • benzthiazide  
  • chlorothiazide  
  • chlorthalidone  
  • hydrochlorothiazide (HCTZ)  
  • hydroflumethiazide  
  • indapamide  
  • methyclothiazide  
  • metolazone  
  • polythiazide  
  • quinethazone  
  • trichlormethiazide

Note: This list may not be all inclusive.

Where Found 

     
  • bendroflumethiazide (Naturetin)  
  • benzthiazide (Exna)  
  • chlorothiazide (Diuril, Diurigen)  
  • chlorthalidone (Thalitone, Hygroton  
  • hydrochlorothiazide (Esidrix, HydroDIURIL, Hydro-Par, Oretic)  
  • hydroflumethiazide (Diucardin, Saluron)  
  • indapamide (Lozol)  
  • methyclothiazide (Enduron, Aquatensen)  
  • metolazone (Zaroxolyn, Diulo)  
  • polythiazide (Renese)  
  • quinethazone (Hydromox)  
  • trichlormethiazide (Metahydrin, Naqua, Diurese)

Note: This list may not be all inclusive.

Symptoms  

     
  • body as a whole       o dizziness       o drowsiness       o fainting       o confusion       o weakness       o coma       o muscle cramps       o frequent urination       o pale-colored urine       o fever  
  • respiratory       o slow breathing  
  • eyes, ears, nose, and throat       o photosensitivity       o color vision abnormalities (yellow tinge)  
  • skin       o rash       o yellow skin  
  • gastrointestinal       o nausea and/or Vomiting  
  • heart and blood vessels       o Low Blood pressure

Home Treatment 
Do not induce Vomiting unless instructed to do so by Poison Control or by a physician.

Before Calling Emergency 
Determine the following information:

     
  • the patient’s age, weight, and condition  
  • the name of the product (ingredients and strengths if known)  
  • the time it was swallowed  
  • the amount swallowed

Poison Control, or a local emergency number 
They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room.

What to expect at the emergency room 
Some or all of the following procedures may be performed:

     
  • induce Vomiting  
  • administer activated charcoal  
  • monitor vital signs ( blood pressure, pulse, and so forth)  
  • monitor EKG(monitors heart function)  
  • blood samples drawn to determine serum electrolyte levels  
  • correction of electrolyte imbalances and fluid imbalances

Expectations (prognosis) 
Patients usually respond well to treatment. Serious symptoms and death are unlikely.

Johns Hopkins patient information

Last revised: December 6, 2012
by Dave R. Roger, M.D.

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All ArmMed Media material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.