Triflupromazine (Injection)

Triflupromazine (Injection)

Triflupromazine (trye-floo-PROE-ma-zeen)

Treats nausea, vomiting, and anxiety before or after surgery.

Brand Name(s):
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to triflupromazine. This medicine should not be used if you have Parkinson’s disease, or Reye’s syndrome.

How to Use This Medicine:


  • Your doctor will prescribe your exact dose and tell you how often it should be given.  
  • An IM injection is a shot given in your muscle (upper arm, thigh, buttocks). An IV infusion is medicine that is put directly into your body through one of your veins.  
  • This medicine should be given by a nurse or other caregiver trained to give IV or IM medicine. Sometimes a family member or friend can be taught to give you this medicine.  
  • Avoid getting this medicine on your skin. If it does get on your skin, rinse the area thoroughly with water.  
  • Triflupromazine is usually light orange or yellow-green. You should not use the medicine if it has changed color.

If a dose is missed:

  • This medicine needs to be given on a regular schedule. If you miss a dose, contact your doctor for instructions.

How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat and light. Do not freeze.  
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also taking insulin, medicine for high blood pressure, muscle relaxants, sedatives, or tranquilizers.  
  • Make sure your doctor knows if you take other medicines that may make you sleepy such as cold or allergy medicines, sleeping pills, tranquilizers, or narcotic pain killers.

Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.  
  • Before using this medicine, let your doctor know if you have heart or lung problems, low or high blood pressure, circulation problems, or a seizure disorder (epilepsy).  
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when outdoors. Avoid sunlamps or tanning beds.  
  • Do not suddenly stop using this medicine without asking your doctor. You may need to use smaller and smaller doses before stopping completely.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Skin rash, itching, or hives  
  • Trouble breathing  
  • Fast or irregular heartbeat  
  • Unexplained high fever, muscle stiffness  
  • Uncontrollable movements of the face, neck, or tongue  
  • Yellowing of eyes or skin

If you notice these less serious side effects, talk with your doctor:

  • Dizziness, weakness, or headache  
  • Pink or brown colored urine  
  • Dry mouth, nose, and throat  
  • Constipation, stomach upset  
  • Muscle or skin discomfort where the shot or IV is given  
  • Breast swelling, discharge, or tenderness  
  • Trouble urinating

Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: July 5, 2011
Last revised: by David A. Scott, M.D.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The drug reference included in this section is provided by Cerner Multum, Inc., of Denver, Colorado. Armenian Medical Network receives monthly updates from Multum.