Trazodone (Oral)

Trazodone (By Mouth)

Trazodone (TRAZ-oh-done)

Treats depression and depression with anxiety.

Brand Name(s):

Desyrel, Desyrel Dividose
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to trazodone.

How to Use This Medicine:


  • Your doctor will tell you how much to take and how often.  
  • Take your medicine with food or shortly after eating.

If a dose is missed:

  • Take the missed dose as soon as possible.  
  • If it is almost time for your next regular dose, wait until then to take your medicine and skip the missed dose.  
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine:

  • Store at room temperature, away from heat, light, and moisture.  
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.  
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are taking digoxin, phenytoin (Dilantinreg;) or medicines that could make you drowsy such as sleeping pills, tranquilizers, other medicine for depression, cold or allergy medicine, or narcotic pain killers.

Warnings While Using This Medicine:

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.  
  • Do not suddenly stop taking this medicine without first checking with your doctor.  
  • You may need to take trazodone for 2 to 4 weeks before you start to feel better.  
  • Get up slowly from a lying or sitting position to decrease dizziness caused by this medicine.  
  • Trazodone can make you dizzy or drowsy. Be careful if driving a car or using machinery.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Skin rash, hives  
  • Unexplained fever or sore throat  
  • Unwanted and painful erection (erect penis) that does not go away

If you notice these less serious side effects, talk with your doctor:

  • Changes in vision such as trouble focusing  
  • Constipation or diarrhea  
  • Drowsiness or dizziness  
  • Dry mouth  
  • Headache  
  • Nausea, vomiting, upset stomach  
  • Nervousness, trouble sleeping


Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: June 21, 2011
Last revised: by David A. Scott, M.D.

Drugs & Medications

  A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The drug reference included in this section is provided by Cerner Multum, Inc., of Denver, Colorado. Armenian Medical Network receives monthly updates from Multum.