Silver Sulfadiazine (Topical)

Silver Sulfadiazine (On The Skin)

Silver Sulfadiazine (SIL-ver sul-fa-DYE-a-zeen)

Treats skin infections in patients with severe burns.

Brand Name(s):

SSD, SSD AF, Thermazene, Silvadene
There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have ever had an allergic reaction to silver sulfadiazine. If you are allergic to sulfa drugs, check with your doctor before using silver sulfadiazine.

How to Use This Medicine:


  • Your doctor will tell you how much to use and how often.  
  • Use this medicine on the skin only. Do not put in or around the eyes.  
  • Wash your hands before and after using the cream.  
  • Before using the cream, clean off any dead skin or scabbing from the burn wound.  
  • Spread a very thin layer of the cream over the wound. You may then cover the wound with a bandage.  
  • Keep the wound area clean at all times.

If a dose is missed::

  • If you forget to use the cream, put some on as soon as you remember.  
  • If the cream washes off during a bath or other activity, clean the wound again and put on more cream.

How to Store and Dispose of This Medicine:

  • Keep the tube of cream at room temperature, away from heat and light. Do not freeze.  
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Check with your doctor before using this medicine if you are pregnant, breastfeeding, or have any medical problems.  
  • If your burn wounds do not heal or if they become worse, call your doctor.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Itchy, red, or swollen skin

If you notice these less serious side effects, talk with your doctor:

  • Skin discomfort when in sunlight  
  • Changes in skin color


Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: July 4, 2011
Last revised: by Janet A. Staessen, MD, PhD

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The drug reference included in this section is provided by Cerner Multum, Inc., of Denver, Colorado. Armenian Medical Network receives monthly updates from Multum.