Factor IX

Factor IX Concentrates injection

What is factor IX injection?
FACTOR IX (AlphaNine®, Bebulin™, BeneFIX®, Konyne®, Mononine®, Prolifnine®, Proplex® T) is a natural protein, normally present in the blood, that helps blood to clot. A lack of this protein is responsible for hemophilia B (Christmas disease). Factor IX helps to prevent or control bleeding in patients with hemophilia B, treats joint bleeds, or prevents bleeding complications during surgery. Some factor IX products may be used to treat patients with inhibitors to factor VIII or factor VII. A number of factor IX products are available and come from human sources.

What should my health care professional know before I receive factor IX?
They need to know if you have any of these conditions:

  • liver disease
  • thrombosis
  • other coagulation problems
  • an unusual or allergic reaction to human or animal (mouse or hamster) protein, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?
Factor IX is for injection into a vein. It is usually given by a health-care professional in a hospital or clinic setting. If you are given factor IX for home use, you will be instructed in the proper injection technique. Follow the directions exactly. Always wash your hands before use. Only use a disposable syringe once. Let the powder and solution warm to room temperature before use. Follow mixing directions carefully to avoid foaming. Swirl but do not shake the solution. Throw away any unused portion.

What if I miss a dose?
Try not to miss doses. Ask your prescriber or health care professional for instructions if you miss a dose.

What drug(s) may interact with factor IX?

  • aminocaproic acid
  • tranexamic acid
  • warfarin

Tell your prescriber or health care professional about all other medicines that you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also, tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from receiving factor IX?
Side effects that you should report to your prescriber or health care professional as soon as possible:

  • chest pain, fast or irregular heartbeat (palpitations)
  • difficulty breathing, wheezing
  • fever or chills
  • skin rash, itching
  • pain, redness or swelling at the injection site

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • flushing
  • headache
  • nausea, vomiting
  • tiredness

What should I watch for while taking factor IX?
As some factor IX products are derived from human plasma, there is a small risk that they may contain certain types of virus or bacteria. All products are processed to kill most viruses and bacteria. If you have questions concerning the risk of viral infections, discuss them with your prescriber or health care professional. If you are a newly diagnosed hemophiliac, you should have a hepatitis A and B vaccination.

If you are a hemophilia patient, carry an identification card with you at all times. The card should have your name, the name and dose of your medication(s), the name and phone number of your prescriber or health care professional, and a contact person in case of emergency.

If you are going to have surgery or a dental procedure, tell your prescriber or health care professional that you use a factor IX product.

Patients should consider enrolling in voluntary programs to be notified of any product recalls.

Where can I keep my medicine?
Keep out of the reach of children.

Store in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F); do not freeze. Follow individual manufacturer’s storage guidelines. Throw away after expiration date. Once the solution has been prepared, use it within 3 hours.

Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: June 11, 2011
Last revised: by David A. Scott, M.D.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The drug reference included in this section is provided by Cerner Multum, Inc., of Denver, Colorado. Armenian Medical Network receives monthly updates from Multum.