Dextromethorphan; Guaifenesin oral solution

What is dextromethorphan; guaifenesin oral solution?
DEXTROMETHORPHAN and GUAIFENESIN (Benylin, Cheracol-D, Robitussin DM, Tussi-Organidin DM and others) decrease a persistent cough caused by colds or flu. Generic dextromethorphan and guaifenesin products are available as prescription or non-prescription medicines, in syrups and solutions.


What should my health care professional know before I take dextromethorphan and guaifenesin?
They need to know if you have any of these conditions:

  • asthma

  • chronic bronchitis

  • emphysema

  • liver disease

  • an unusual or allergic reaction to dextromethorphan, guaifenesin, other medicines, foods, dyes, or preservatives (some combination products contain bromides)

  • pregnant or trying to get pregnant

  • breast-feeding

    How should I take this medicine?
    Take dextromethorphan and guaifenesin by mouth. Follow the directions on the container. Use a specially marked spoon or container to measure your dose. Ask your pharmacist if you do not have one; household spoons are not always accurate. Take your doses at regular intervals. Do not take your medicine more often than directed.

    Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

    What if I miss a dose?
    If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

    What drug(s) may interact with dextromethorphan and guaifenesin?

  • alcohol

  • amiodarone

  • furazolidone

  • linezolid

  • medicines known as MAO inhibitors, such as phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Carbex, Eldepryl)

  • medicines for mental depression or other mental disturbances

  • quinidine

    Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

    What side effects may I notice from taking dextromethorphan and guaifenesin?
    Severe side effects from dextromethorphan and guaifenesin are usually only seen in patients who have taken very high doses. These side effects should be reported to your prescriber or health care professional as soon as possible:

  • confusion

  • excitement, nervousness, restlessness, or irritability

  • severe nausea, vomiting

  • slurred speech
    Children may get the following side effects from an overdose:

  • seizures

  • shaky movements

  • slow or troubled breathing

    Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
    Rare or uncommon:

  • dizziness, drowsiness

  • hives

  • nausea, vomiting

  • rash

  • stomach ache

    What should I watch for while taking dextromethorphan and guaifenesin?
    If you have a fever, skin rash, or persistent headache as well as a cough, see your prescriber or health care professional. Do not treat yourself for a cough for more than one week without consulting your prescriber or health care professional.

    You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how dextromethorphan and guaifenesin affects you. Alcohol can increase the risk of getting drowsy, dizzy or confused. Avoid alcoholic drinks.

    Drink plenty of water while taking dextromethorphan and guaifenesin products. This will help loosen mucus.

    Where can I keep my medicine?
    Keep out of the reach of children in a container that small children cannot open.

    Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) unless otherwise directed. Throw away any unused medicine after the expiration date.


    NOTE: This information is not intended to cover all possible uses, precautions, interactions, or adverse effects for this drug. If you have questions about the drug(s) you are taking, check with your health care professional.

    Johns Hopkins patient information

    Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
    Revision date: June 20, 2011
    Last revised: by Dave R. Roger, M.D.

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