Benazepril; Hydrochlorothiazide

Benazepril; Hydrochlorothiazide, HCTZ tablets

What are benazepril; hydrochlorothiazide tablets?
BENAZEPRIL-HYDROCHLOROTHIAZIDE (Lotensin® HCT) is a combination of two drugs used to lower blood pressure. Benazepril is an ACE inhibitor that controls high blood pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a diuretic. High blood pressure can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. By lowering blood pressure, benazepril-hydrochlorothiazide can help reduce your risk of having damage to your kidneys, heart, or other organs. This medicine does not cure high blood pressure. Generic benazepril-hydrochlorothiazide tablets are available.

What should my health care professional know before I take benazepril-hydrochlorothiazide?
They need to know if you have any of these conditions:

  • autoimmune disease (e.g., lupus), or suppressed immune function
  • previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat (angioedema)
  • bone marrow disease
  • diabetes mellitus
  • gout
  • heart or blood vessel disease
  • liver disease
  • recent heart attack or stroke
  • kidney disease, (e.g. renal failure or renal artery stenosis)
  • pancreatitis
  • electrolyte imbalance (e.g. low or high levels of potassium in the blood)
  • if you are on a special diet, such as a low-salt diet (e.g. using potassium substitutes)
  • sulfonamide (sulfa) or thiazide allergy
  • an unusual or allergic reaction to benazepril, hydrochlorothiazide, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?
Take benazepril-hydrochlorothiazide tablets by mouth. Follow the directions on the prescription label. You may take benazepril-hydrochlorothiazide with or without food. Swallow the tablets with a drink of water. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine except on your prescriber’s advice.

Many patients with high blood pressure will not notice any signs of the problem. Therefore, it is very important that you take this medicine exactly as directed and that you keep your appointments with your prescriber or health care professional even if you feel well.

Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What drug(s) may interact with benazepril-hydrochlorothiazide?

  • antiinflammatory drugs (NSAIDs, such as ibuprofen)
  • blood pressure medications
  • cholesterol-lowering medications (e.g. cholestyramine or colestipol)
  • diabetic medications
  • dofetilide
  • hawthorn
  • lithium
  • potassium salts or potassium supplements
  • water pills (especially potassium-sparing diuretics such as triamterene or amiloride)

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking benazepril-hydrochlorothiazide?
Side effects that you should report to your prescriber or health care professional as soon as possible:
Rare or uncommon:

  • difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • swelling of your face, lips, tongue, hands, or feet
  • unusual rash, bleeding or bruising, or pinpoint red spots on the skin


  • confusion, dizziness, lightheadedness or fainting spells
  • decreased amount of urine passed
  • decreased sexual function
  • fast or uneven heart beat, palpitations, or chest pain
  • fever or chills
  • irregular heartbeat
  • muscle cramps
  • stomach pain
  • vomiting
  • unusual tiredness or weakness
  • worsened gout pain
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

  • cough
  • diarrhea
  • headache
  • increased sensitivity to the sun
  • nausea
  • tiredness or fatigue

What should I watch for while taking benazepril-hydrochlorothiazide?
Check your blood pressure regularly while you are taking benazepril-hydrochlorothiazide. Ask your prescriber or health care professional what your blood pressure should be and when you should contact him or her. When you check your blood pressure, write down the measurements to show your prescriber or health care professional. You must not get dehydrated, ask your prescriber or health care professional how much fluid you need to drink a day. If you are taking this medicine for a long time you must visit your prescriber or health care professional for regular checks on your progress. Make sure you schedule appointments on a regular basis.

Check with your prescriber or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take benazepril-hydrochlorothiazide.

You may get dizzy. Do not drive, use machinery, or do anything that requires mental alertness until you know how benazepril-hydrochlorothiazide affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly. Alcohol may increase the possibility of dizziness. Avoid alcoholic drinks until you have discussed their use with your prescriber or health care professional.

If you are going to have surgery tell your prescriber or health care professional that you are taking benazepril-hydrochlorothiazide.

Benazepril-hydrochlorothiazide may affect your blood sugar level. If you have diabetes, check with your prescriber or health care professional before changing the dose of your diabetic medicine.

Avoid salt substitutes unless you are told otherwise by your prescriber or health care professional. Do not take medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems without asking your prescriber or health care professional for advice. Do not treat yourself for a fever or sore throat; check with your prescriber or health care professional first.

Where can I keep my medicine?
Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture and light. Keep container tightly closed. Throw away any unused medicine after the expiration date.

Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: July 7, 2011
Last revised: by Dave R. Roger, M.D.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The drug reference included in this section is provided by Cerner Multum, Inc., of Denver, Colorado. Armenian Medical Network receives monthly updates from Multum.