Aciphex/Rabeprazole is used to treat conditions where the stomach produces too much acid, including ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome. Aciphex/Rabeprazole is used in combination with other medications.

Aciphex is a proton pump inhibitor (PPI) used to treat ulcers, gastroesophageal reflux (GERD), erosive esophagitis, or Zollinger-Ellison syndrome. Aciphex works by blocking acid production in the stomach. It may be used in combination with antibiotics (e.g., amoxicillin, clarithromycin) to treat certain types of ulcers. It may also be used to treat other conditions as determined by your doctor.

Aciphex Usage
Aciphex/Rabeprazole comes as a delayed-release (long-acting) tablet to take by mouth. Aciphex is usually taken once a day for extended periods of time. When taken for ulcers, Aciphex/rabeprazole should be taken after the morning meal.

Swallow the Aciphex tablets whole; do not split, chew, or crush them.
What special precautions should I follow?
Before taking Aciphex/rabeprazole,

  • Tell your doctor if you are allergic to rabeprazole, lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or any other medications.  
  • Tell your doctor and what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following medicines: cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin), and ketoconazole (Nizoral). Your doctor may need to change the doses of your medications or monitor you carefully for Aciphex side effects.  
  • Tell your doctor if you have active or inactive liver disease.  
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Aciphex/rabeprazole, call your doctor.

Possible side effects
NO COMMON SIDE EFFECTS HAVE BEEN REPORTED with the proper use of Aciphex . If you notice any unusual effects, contact your doctor, nurse, or pharmacist.

ACIPHEX has a well-established safety record. The most common side effect possibly related to ACIPHEX is headache. Symptom relief does not rule out other serious stomach conditions. Patients also on warfarin (such as Coumadinreg;) may need to be monitored more closely by their doctor.

For more information about the safety profile of Aciphex and possible side effects, please discuss the important product information with your doctor.

Treatment with Aciphex
Take Aciphex as prescribed by your doctor. Taking Aciphex once a day reduces the amount of acid in your stomach, helping to relieve your heartburn symptoms and helping you feel better. It is very important that you keep taking Aciphex for as long as your doctor tells you.

Aciphex tablets should be swallowed whole. They should not be chewed, crushed, or split. If you have any questions, please talk to your doctor, healthcare provider, or pharmacist.
Who should not take Aciphex?
Although serious allergic reactions to Aciphex are rare, the medication should not be used if you have had a reaction to Aciphex, any of the tablet ingredients, or another PPI (proton pump inhibitor).

Although it is not known whether Aciphex is excreted in human breast milk, many drugs are. Because of the potential for adverse reactions to nursing infants from Aciphex, a decision should be made to either discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Be sure to inform your doctor of any medical conditions you have and any medications you are taking, so he or she can determine whether Aciphex is right for you.
Can I take Aciphex during pregnancy?
The safety and efficacy of Aciphex for use by pregnant women has not been established. Please speak with your doctor before using Aciphex or any other medication while pregnant.

Can I take Aciphex if I am a nursing mother?
If you are a nursing mother, please speak to your physician before using Aciphex or any other medication.

Additional information
If you are taking Aciphex for gastric ulcers or reflux disease, your symptoms should improve within 4 to 8 weeks. If your symptoms do not improve or if they become worse, contact your doctor. DO NOT SHARE Aciphex with others for whom it was not prescribed. DO NOT USE Aciphex for other health conditions.
Aciphex Storage
KEEP Aciphex out of the reach of children and pets. IF USING Aciphex FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs out.

Aciphex Prices

Johns Hopkins patient information

Copyright 1996-2014 Cerner Multum, Inc. Version: 16.02.
Revision date: June 20, 2011
Last revised: by Jorge P. Ribeiro, MD

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