Trigeminal Neuralgia (Tic Douloureux)


What Is It?

Trigeminal neuralgia, also known as tic douloureux, is a painful disorder of a nerve in the face called the trigeminal nerve or fifth cranial nerve. There are two trigeminal nerves, one on each side of the face. They are responsible for detecting touch, pain, temperature and pressure sensations in areas of the face between the jaw and forehead.

People who have trigeminal neuralgia typically experience episodes of sudden, intense, “stabbing” or “shocklike” facial pain. This pain can occur almost anywhere between the jaw and forehead, including inside the mouth. However, it usually is limited to one side of the face.

In some cases, the cause of trigeminal neuralgia is unknown. In many people, however, the disorder seems to be related to a local irritation of the trigeminal nerve, usually in the area of the nerve root deep within the skull. In most cases, the source of this irritation is believed to be an abnormal blood vessel pressing on the nerve. Less often, the nerve irritation is related to a tumor that involves the brain or nerves, or to a rare type of stroke. In addition, up to 8 percent of patients who suffer from multiple sclerosis (MS) eventually develop trigeminal neuralgia as a result of MS-related nerve damage.

New cases of trigeminal neuralgia affect four to five out of every 100,000 people in the United States each year. It affects women slightly more often than men, perhaps because the disease is most common in older people and women live longer. In most cases, the first episode of facial pain occurs when the patient is 50 to 70 years old. Although infants, children and young adults may develop this disorder, it is rare in people younger than age 40.


Trigeminal neuralgia causes episodes of sudden, intense facial pain that usually last for two minutes or less. In most cases, the pain is described as excruciating, and its quality is “sharp,” “stabbing,” “piercing,” “burning,” “like lightning” or “like an electric shock.” In most cases, only one side of the face is affected.

The pain of trigeminal neuralgia is recognized as one of the most excruciating forms of pain known. The pain often is triggered by nonpainful facial movements or stimuli, such as talking, eating, washing the face, brushing the teeth, shaving or touching the face lightly. In some cases, even a gentle breeze on the cheek is enough to trigger an attack. Approximately 50 percent of patients also have specific trigger points or zones on the face, usually located somewhere between the lips and nose, where an episode of trigeminal neuralgia can be triggered by a touch or a temperature change. In some cases, a sensation of tingling or numbness comes before the pain.

Attacks of trigeminal neuralgia can vary significantly, and may occur in clusters, with several episodes following in series over the course of a day. For unknown reasons, trigeminal neuralgia almost never occurs at night when the person is sleeping.

In addition to pain, some patients simultaneously have a cheek twitch or muscle spasm, wincing, a facial flush, a tearing eye or salivation on the same side of the face. It is the facial muscle spasms that led to the older term, tic douloureux (from French, tic means muscle twitch or spasm; douloureux means painful).


Your doctor will ask about your symptoms and your medical history, including any history of multiple sclerosis, a condition that may cause similar or even identical symptoms. To help rule out medical and dental conditions that can mimic trigeminal neuralgia, the doctor also asks whether you have a history of:

  • Recent trauma to your face or teeth
  • A recent tooth infection or root-canal treatment
  • A tooth extraction on the same side as your facial pain — Sometimes a tooth extraction can cause pain in the area of the missing tooth.
  • Any areas of painful facial blisters — Painful blisters can be a sign that you have a viral infection involving your facial skin, such as herpes, which is caused by the herpes simplex virus, or shingles, which is caused by varicella zoster, the chickenpox virus. Facial pain can persist for weeks after the blisters heal, especially in cases of shingles.

Next, your doctor will thoroughly examine your head and neck, including the area inside your mouth. The doctor also will do a brief neurological examination and concentrate on feeling and muscle movements in your face. In almost all cases of trigeminal neuralgia, the results of these examinations are normal. If necessary, your doctor will order a magnetic resonance imaging (MRI) or computed tomography (CT) scan of your head to check for blood-vessel abnormalities, tumors pressing on your trigeminal nerve or other possible causes of your symptoms.

Your doctor will diagnose trigeminal neuralgia based on your symptoms, the examination and test results. There is no specific test to confirm the diagnosis of trigeminal neuralgia, so an important part of the diagnosis is excluding other explanations for the symptoms. In some cases, the doctor prescribes a brief course of carbamazepine (Tegretol and others), which is used to treat trigeminal neuralgia. A good response to this medication supports the diagnosis of trigeminal neuralgia.

Expected Duration

Trigeminal neuralgia is unpredictable. For unknown reasons, many people experience periods when the illness suddenly intensifies and produces repeated painful episodes over the course of several days, weeks or months. This period may be followed by a pain-free interval that can last for months or years.

The type of treatment that you receive may influence the duration of your symptoms. Some treatments carry a higher risk that the symptoms will return.


Because the cause of trigeminal neuralgia is unknown, it cannot be prevented.


The first treatment for trigeminal neuralgia usually is carbamazepine (Tegretol and others). Carbamazepine is an anticonvulsant medication that decreases the ability of the trigeminal nerve to fire off the nerve impulses that cause facial pain. If carbamazepine is not effective, other possible drug choices include phenytoin (Dilantin), baclofen (Lioresal), gabapentin (Neurontin), lamotrigine (Lamictal), clonazepam (Klonopin) and valproic acid (Depakene, Depakote). These may be taken individually or in combination. One study found that when trigeminal neuralgia is related to multiple sclerosis, misoprostol (Cytotec), a medication usually prescribed to prevent stomach ulcers, may be effective. Narcotic pain relievers, such as oxycodone (OxyContin) or morphine (several brand names), may be recommended briefly for severe episodes of pain. Some of these medications carry the risk of unpleasant side effects, including drowsiness, liver problems, blood disorders, nausea, dizziness, overgrowth of the gums and skin rashes. For this reason, people taking any of these medications may be monitored with frequent follow-up visits and periodic blood tests. After a few pain-free months, your doctor may attempt to decrease the dose of the medication gradually or discontinue it. This is done to limit the risk of side effects and to determine whether your trigeminal neuralgia has gone away on its own.

If medication does not stop your pain or if you cannot tolerate the side effects of medication, then your doctor may suggest one of the following treatment options:

  • Rhizolysis (selective destruction of part of the trigeminal nerve) — In this approach, a portion of the trigeminal nerve is inactivated temporarily by using one of the following methods: a heated probe, an injection of the chemical glycerol or a tiny balloon that is inflated near the nerve to compress it. During the procedure a needle or a tiny hollow tube called a trocar is inserted through the skin of your cheek. These procedures provide immediate relief in up to 99 percent of patients, but 25 percent to 50 percent of people will have the problem return during the next several years.

  • Stereotactic radiosurgery — This form of radiation therapy uses a linear accelerator or a gamma knife to inactivate part of the trigeminal nerve. After your head is positioned carefully in a special head frame, many tiny beams of radiation are aimed precisely at the portion of the trigeminal nerve that must be inactivated. Stereotactic radiosurgery is a fairly new treatment option for trigeminal neuralgia, and its long-term success rate is still being evaluated.

  • Microvascular decompression of the trigeminal nerve — In this delicate surgical procedure, a surgeon carefully repositions the blood vessel that is pressing on your trigeminal nerve near your brain. Because this procedure involves opening your skull, the ideal candidate for this procedure is someone who is generally healthy and younger than 65. Overall, the immediate success rate is approximately 90 percent, and 70 percent to 80 percent of patients have long-term relief. Microvascular decompression may be effective for patients who have not had success with one of the less-invasive surgeries.

When To Call A Professional

You should seek medical help immediately if you develop facial pain that fits the pattern of trigeminal neuralgia.


In most cases, the prognosis is good. Approximately 80 percent of patients become pain-free with medication alone. When medication fails or produces unwanted side effects, other treatment options are available and also have a high rate of success.

Johns Hopkins patient information

Last revised:

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All ArmMed Media material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.