Statins

There are currently five statin drugs on the market in the United States: lovastatin, simvastatin, pravastatin, fluvastatin, and atorvastatin (cerivastatin was withdrawn from the market by the manufacturer in August 2001). The major effect of the Statins is to lower LDL-cholesterol levels, and they lower LDL-cholesterol more than other types of drugs. Statins inhibit an enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. These drugs lower cholesterol by slowing down the production of cholesterol and by increasing the liver’s ability to remove the LDL-cholesterol already in the blood. Statins were used to lower cholesterol levels in both the West of Scotland and AFCAPS/TexCAPS studies. The large reductions in total and LDL-cholesterol produced by these drugs resulted in large reductions in heart attacks and heart disease deaths.

Thanks to their track record in these studies and their ability to lower LDL-cholesterol, Statins have become the drugs most often prescribed when a person needs a cholesterol-lowering medicine.

Studies using Statins have reported 20 to 60 percent lower LDL-cholesterol levels in patients on these drugs. Statins also reduce elevated triglyceride levels and produce a modest increase in HDL-cholesterol.

The Statins are usually given in a single dose at the evening meal or at bedtime. It is important that these medications be given in the evening to take advantage of the fact that the body makes more cholesterol at night than during the day.
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Lipitor is used for those who have abnormally High cholesterol levels. When taken together with a low-fat diet, this medicine can effectively reduce LDL cholesterol, commonly referred to as the “bad” cholesterol, triglyceride levels, and total cholesterol, while increasing the HDL, or “good” cholesterol.

More information about Lipitor (Atorvastatin)

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You should begin to see results from the Statins after several weeks, with a maximum effect in 4 to 6 weeks. After about 6 to 8 weeks, your doctor can do the first check of your LDL-cholesterol while on the medication. A second measurement of your LDL-cholesterol level will have to be averaged with the first for your doctor to decide whether your dose of medicine should be changed to help you meet your goal.

The Statins are well tolerated by most patients, and serious side effects are rare. A few patients will experience an upset stomach, gas, constipation, and abdominal pain or cramps. These symptoms usually are mild to moderate in severity and generally go away as your body adjusts. Rarely a patient will develop abnormalities in blood tests of the liver. Also rare is the side effect of muscle problems. The symptoms are muscle soreness, pain, and weakness. If this happens, or you have brown urine, contact your doctor right away to get blood tests for possible muscle problems.

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Zocor is used to lower levels of cholesterol and other fats in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels.
Simvastatin (SIM-va-stat-in)
Brand Name: Zocor

More information about Zocor (Simvastatin)

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RELATED STORIES:
Dietary changes that may be helpful   Lifestyle changes that may be helpful   Does lowering LDL cholesterol prevent heart attacks and strokes?   High Blood cholesterol: Sample Menus   What are lipid-altering medications?   High Blood cholesterol: Glossary of terms   The recommended treatment: A blood cholesterol-lowering diet   Why is HDL the good cholesterol?   What are LDL and HDL cholesterol?   Cholesterol Lowering Treat   Cholesterol: high blood levels   Cholesterol too high? Medications can help

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