Pregnancy hormone shows promise in heart failure

	Tweet

A pregnancy hormone that relaxes blood vessels appeared to reduce symptoms of acute heart failure and improve survival, according to a preliminary study released by U.S. researchers on Sunday.

They said the hormone relaxin, which is being developed by privately held Corthera Inc of California, was safe, and showed signs of reducing the risk of death from heart problems during the study.

The findings suggest that “early administration of this drug, in addition to standard therapy, might be associated with more rapid, sustained and complete resolution of acute heart failure, as well as with more favorable long-term outcomes,” John Teerlink of the University of California, San Francisco, and colleagues wrote in the journal Lancet.

"If established in larger studies, the benefits of relaxin might represent an important advance in the treatment of patients with acute heart failure,” the researchers wrote.

In pregnancy, the hormone helps relax and lengthen the cervix to prepare for childbirth, but it is also thought to be a natural vasodilator, widening blood vessels and allowing blood to flow more freely.

Vasodilators are often given to people with High Blood Pressure, which is common in heart failure, a condition in which the heart gradually loses its ability to pump blood efficiently, leaving organs starved for oxygen.

Teerlink and colleagues studied 234 elderly patients with heart failure and High Blood Pressure who were given either a 48-hour intravenous infusion of the drug or a placebo.

They found it was safe and helped to reduce shortness of breath in 40 percent of patients who received a moderate dose of the drug, compared with 23 percent who took a placebo.

It also reduced the number of patients in the study who died from heart problems or were readmitted to the hospital within two months for kidney failure compared with the placebo, according to the results, which were also presented at the American College of Cardiology meeting in Florida.

An estimated 5.3 million Americans have heart failure, a chronic but often deadly condition that will cost $34.8 billion this year for direct and indirect U.S. treatment costs, according to the American Heart Association.

CHICAGO (Reuters)

RELATED STORIES:
Scientists turn skin cells into beating heart muscle   Too many people get angioplasties, study suggests   New Blood Thinner May Lower Chances of Clots in High-Risk Heart Patients: FDA   Heart Damage After Chemo Linked to Stress in Cardiac Cells   What’s good or bad for the heart, may be the same for the brain   Warfarin in Heart Failure   Increased Sudden Cardiac Death Rate Among HIV Patients   Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease   Lack of basic evidence hampering prevention of sudden heart attacks in sport   Blacks Less Likely to Get Help on Scene After Cardiac Arrest: Study   Heart attack patients taken to PCI hospitals first treated faster   Cameron Health’s under-skin ICD safe, effective

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]