Updated Alzheimer’s guidelines add very early stage

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Proposed new guidelines for diagnosing Alzheimer’s released on Tuesday would look at the disease at its earliest stages, when clumps of a protein called amyloid are just beginning to form in the brains of people who are otherwise healthy.

This pre-clinical stage about 10 years before dementia sets in is seen as the best place to intervene in the disease, and it is why new imaging agents for PET scans, spinal fluid tests and other so-called biomarkers that predict Alzheimer’s are becoming so important to researchers and drug companies.

The changes, presented at the Alzheimer’s Association meeting in Honolulu, are the first update of the criteria used to diagnose Alzheimer’s disease in more than 25 years. They are the work of three expert panels put together by the National Institute on Aging and the Alzheimer’s Association.

They suggest Alzheimer’s should be diagnosed in three stages - advanced disease, mild disease and the new category called pre-clinical disease.

“I think we’re realizing that the process of Alzheimer’s disease begins many years before dementia,” Dr. Reisa Sperling of Brigham and Women’s Hospital in Boston, who led the group on pre-clinical Alzheimer’s disease, said in an interview.

Many researchers believe most Alzheimer’s drugs have failed because they were tried in people whose disease was too advanced to do any good.

Currently, only an autopsy can confirm that a person has Alzheimer’s disease, a fatal and incurable deterioration of the brain that affects more than 26 million people globally.

Doctors diagnose Alzheimer’s by excluding other potential causes of memory loss, such as stroke, tumors and heavy drinking. They can also administer simple paper-and-pencil tests.

Bill Thies, chief medical officer of the Alzheimer’s Association, said the changes reflect an increased scientific understanding of Alzheimer’s, including the use of biomarkers tracked by brain scans, blood and spinal fluid tests.

Many of these new tests will still need to be validated before the recommendations are fully adopted, Thies said.

“I do think it is useful to stage Alzheimer’s disease,” said Sperling, who runs clinical trials on Alzheimer’s drugs.

She said many diseases, including cancer, heart disease and kidney disease, are diagnosed on the basis of tests, even before symptoms appear.

“We shouldn’t put Alzheimer’s disease to a higher standard than we do every other disease,” she said.

The guidelines are just the first step. The NIA, a part of the National Institutes of Health, and the Alzheimer’s Association are seeking comment on the new guidelines from other Alzheimer’s experts, and they plan to include those comments and publish them in a medical journal.

Current Alzheimer’s drugs only treat symptoms, but so far no drugs can change the course of the disease.

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By Julie Steenhuysen

HONOLULU (Reuters)

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