Testosterone doesn’t boost functioning in older men

Older men who use testosterone gel may see small improvements in their muscle-to-fat ratio but are unlikely to glean any benefits in flexibility, endurance and general ability to get around, new research suggests.

Men participating in the study had low to normal testosterone levels, were at least 60 years old and were functioning at a relatively high level to begin with. It’s still unclear how long-term use of testosterone might affect frailer and more disease-prone elderly men, researchers noted.

“There may be specific populations of men for whom testosterone supplementation or replacement may be beneficial,” said lead author Dr. Kerry Hildreth, from the University of Colorado School of Medicine in Aurora.
“But it’s really not clear that in otherwise healthy, functional men in that low-normal physiologic range that using testosterone either alone or in combination with exercise added much.”

The new findings, she said, suggest that testosterone “is widely used in people where it really may not be appropriate or may not provide the benefits that people think it’s going to.”

Abbott donated the testosterone gel used in the study, Androgel. The gel is approved by the U.S. Food and Drug Administration for men who make too little testosterone on their own, a condition called hypogonadism.

Because testosterone levels decline naturally as men age, some researchers have wondered if treating older, healthy men with the hormone could help slow changes in body composition and loss of strength.

To try to answer that question, Hildreth and her colleagues randomly assigned 167 older men to use testosterone or a hormone-free placebo gel each day and to do strength-training three times a week or not.

Use of testosterone was tied to a two-pound decrease in fat mass and a two-pound increase in muscle mass, the study team reported in The Journal of Clinical Endocrinology & Metabolism.

Men who weren’t told to exercise also saw improvements in upper body strength during a year of testosterone use, compared to placebo gel users.

Exercise alone led to improvements in body composition - but testosterone and strength training did not appear to have an additive benefit, the researchers found. And with or without an exercise program, testosterone gel did not improve men’s daily functioning in tasks like climbing stairs or getting up from a chair.

Studies have come to contradictory conclusions on the effect of extra testosterone on men’s health and physical abilities, Hildreth’s team noted.

“A number of studies have shown consistent improvements in body composition… but they don’t seem to translate into significant improvements in function,” Hildreth told Reuters Health.

Some research has suggested that although testosterone may help improve muscle strength in frail, elderly men, the effects don’t last after treatment stops (see Reuters Health story of Dec 3, 2010 here: reut.rs/jt9Tvr).

AbbVie, a spinoff from Abbott that markets Androgel in the U.S., was not able to not provide a comment before press time.

Men in the current study seemed to tolerate testosterone well, Hildreth noted. But there are still long-term concerns about side effects, such as abnormal blood counts and elevated prostate specific antigen levels.

“People should be careful about using it,” she said.

SOURCE: The Journal of Clinical Endocrinology & Metabolism, online March 26, 2013.


Effects of Testosterone and Progressive Resistance Exercise in Healthy, Highly Functioning Older Men With Low-Normal Testosterone Levels

Results: A total of 143 men completed the study. At 12 months, total T was 528 ± 287 ng/dL in subjects receiving any T and 287 ± 65 ng/dL in the placebo group. In the PRT group, function and strength were not different between T- and placebo-treated subjects, despite greater improvements in fat mass (P = .04) and fat-free mass (P = .01) with T. In the non-PRT group, T did not improve function but improved fat mass (P = .005), fat-free mass (P = .03), and upper body strength (P = .03) compared with placebo. There were fewer cardiovascular events in the T-treated groups compared with placebo.

Conclusions: T supplementation was well tolerated and improved body composition but had no effect on functional performance. T supplementation improved upper body strength only in nonexercisers compared with placebo.

  Kerry L. Hildreth,
  Daniel W. Barry,
  Kerrie L. Moreau,
  Joseph Vande Griend,
  Randall B. Meacham,
  Tammie Nakamura,
  Pamela Wolfe,
  Wendy M. Kohrt,
  J. Mark Ruscin,
  John Kittelson,
  M. Elaine Cress,
  Robert Ballard and
  Robert S. Schwartz

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