Taste genes predict tooth decay

	Tweet

Dental caries is a highly prevalent disease that is disproportionately distributed in the population. Caries occurrence and progression is known to be influenced by a complex interplay of both environmental and genetic factors, with numerous contributing factors having been identified including bacterial flora, dietary habits, fluoride exposure, oral hygiene, salivary flow, salivary composition, and tooth structure. Previous reports have characterized the influence of the genetic variation on taste preferences and dietary habits.

In an article published in the Journal of Dental Research titled “Taste Genes Associated with Dental Caries” lead researcher Steven Wendell and researchers Melissa Brown, Margaret Cooper, Rebecca DeSensi, Mary Marazita, Xiaojing Wang and Robert Weyant, all from the University of Pittsburgh; and Richard Crout and Daniel McNeil from West Virginia University, hypothesized that genetic variation in taste pathway genes (TAS2R38, TAS1R2, GNAT3) may be associated with dental caries risk and/or protection.

In this study, families were recruited by the Center for Oral Health Research in Appalachia (COHRA) for collection of biological samples, demographic data and clinical assessment of oral health including caries scores.

Multiple single nucleotide polymorphism (SNP) assays for each gene were performed and analyzed using transmission disequilibrium test (TDT) analysis (FBAT software) for three dentition groups- primary, mixed, and permanent. Statistically significant associations were seen in TAS2R38 and TAS1R2 for caries risk and/or protection.

“This work is significant in that it identifies key genes that may explain the susceptibilities of some patients to Tooth decay,” said JDR Editor-in-Chief William Giannobile. “Although an early study, this breakthrough on taste pathways and genes demonstrates how patient preferences that are genetically predetermined may put patients at risk for disease.”

An accompanying editorial titled “Defining the Contribution of Genetics in the Etiology of Dental Caries” has been published. J. Tim Wright, The University of North Carolina, Chapel Hill, states “given that the majority of oral health care costs are directed at treating the ravages of dental caries, this line of research would seem appropriate.”

###

About the Journal of Dental Research

The Journal of Dental Research is a multidisciplinary journal dedicated to the dissemination of new knowledge in all sciences relevant to dentistry and the oral cavity and associated structures in health and disease. At 4.195, the JDR holds the highest Five-Year Impact Factor of all dental journals publishing original research, with a cited half-life >10 years, reflecting the influential nature of the Journal’s content. It also has the highest Eigenfactor Score in the field.

About the International Association for Dental Research

The International Association for Dental Research (IADR) is a nonprofit organization with more than 12,000 individual members worldwide, dedicated to - (1) advancing research and increasing knowledge to improve oral health, (2) supporting the oral health research community, and (3) facilitating the communication and application of research findings for the improvement of oral health worldwide.  The American Association for Dental Research (AADR) is the largest Division of IADR, with nearly 4,000 members in the United States.

Ingrid L. Thomas

703-299-8084
International & American Association for Dental Research

RELATED STORIES:
Gene predicts response to hepatitis C drugs: study   Scientists find five new Alzheimer’s risk genes   Genetic mutation wakes families before sunrise   Genetic factors influence male homosexuality - study   Genetic variation affects smoking cessation treatment   Einstein researchers find key gene in childhood cancer   Genes and timing of menopause   Gene therapy proves effective for hemophilia B   Good Diets Fight Bad Alzheimer Genes   Genetic Abnormalities May Cause Cerebral Palsy   Can our genes be making us fat?   Mouse gene suppresses Alzheimer’s plaques and tangles

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]