Stroke Risk Gene Confirmed

	Tweet

In an important confirmation of genetic influences in Stroke, researchers have found an association between a major risk gene and Stroke in young adults, according to a report presented at the 130th annual meeting of the American Neurological Association in San Diego.

The gene, called phosphodiesterase 4D (PDE4D), had first been found to increase the risk of Stroke in a study in Iceland, and other studies involving primarily older white populations have lent support for this finding.

A team of researchers from several institutions has now confirmed this result in a biracial group of young American women. 

They identified a structural variation, or polymorphism, in the gene that was associated with increased risk of Stroke in both young black women and young white women. Furthermore, this association is present for small blood vessel disease as well as for large artery Atherosclerosis.

The import of these results is confined to research for the moment. “Before our results can be used clinically, the underlying biological mechanisms for this association must be understood,” said study author John W. Cole, MD, MS, of the Baltimore Department of Veterans Affairs Medical Center and the University of Maryland School of Medicine, Baltimore, MD.

Identifying risk genes in Stroke is particularly difficult because many genes appear to combine with a variety of environmental risk factors ranging from smoking to use of oral contraceptives.

The identification of the PDE4D gene is thus an important advance. Several other studies have examined the association of PDE4D with stroke in different populations and most studies provide support for the original Icelandic findings. The next challenge is to determine the specific gene variations responsible for the association and how they influence the proteins that are coded for by the PDE4D gene.

“For example, does the genetic variant cause one to produce a defective protein, or decrease or increase the level of a protein, thereby predisposing to stroke? Does the variant make an individual more susceptible to stroke given a specific environmental exposure?” said Cole.

Only when these questions have been answered, would there be a value in developing a genetic test to determine which polymorphisms are present in a person’s genome.

“The results of these tests would allow practitioners to counsel patients on stroke risk and to warn patients that specific environmental factors, such as oral contraceptive use, diet or smoking may be particularly harmful,” said Cole.

Another important application will be to develop drugs that reduce stroke risk by specifically targeting the gene or its products.

RELATED STORIES:
Early Treatment Delays Multiple Sclerosis Progression   Eating Fish May Prevent Memory Loss and Stroke in Old Age   Calorie Restriction May Prevent Alzheimer’s Disease   Are You at Risk for Carpal Tunnel Syndrome?   Long-lasting Nerve Block Could Change Pain Management   Depression Increases Risk of Alzheimer’s Disease   Students Step Closer to Technological Breakthrough in Paralysis Treatment   Researchers identify why dopamine replacement therapy has a paradoxical effect on cognition   Botox injections may ease diabetic foot pain   Stroke patients benefit from early home rehab   Traumatic Brain Injury in Professional Football: An Evidence-based Perspective   Tests May Predict Driving Safety in People with Alzheimer’s Disease

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]