Processed Soy Products Linked To Tumour Growth

	Tweet

Highly purified soy foods and supplements sold in the United States may stimulate the growth of pre-existing estrogen dependent breast tumors, according to a study from the University of Illinois.

“Soy has been correlated with low rates of breast cancer in Asian populations, but soy foods in Asia are made from minimally processed soybeans or defatted, toasted soy flour, which is quite different from soy products consumed in the U.S.,” said William G. Helferich, a professor of food science, in a study published in the journal Carcinogenesis.

"Isoflavone-containing products consumed in the U.S. may have lost many of the biologically active components in soy, and these partially purified isoflavone-containing products may not have the same health benefits as whole soy foods,” he said.

Soy isoflavone products are marketed as dietary estrogens to women over age 50 as a natural alternative to hormone replacement therapy.

Seventy-five percent of breast cancer cases are diagnosed in women over 50, and the majority of these cases are estrogen-dependent. For these women, Helferich said, consumption of highly processed isoflavone products may pose a risk.

Helferich used an animal model that has been used extensively to evaluate breast cancer therapies such as tamoxifen. “The results of this preclinical investigation are especially relevant to postmenopausal women with estrogen-responsive breast cancers who are looking for alternatives to HRT,” he said.

In the study, mice were fed equal concentrations of the soy isoflavone genistein, allowing Helferich to determine the influences that various bioactive soy compounds had on genistein’s ability to stimulate estrogen-dependent breast tumor growth. “As bioactive compounds were removed, we observed an increase in estrogen-dependent tumor growth,” he said.

If genistein had been the only biologically active compound, all diets would have resulted in similar tumor growth, but that was not the case, he said.

A soy flour and mixed isoflavones diet and a mixed isoflavone diet each contained equal amounts of genistein, but differed in the amount of other bioactive components originally present in the soy flour. Tumors neither grew nor regressed in animals fed these diets. “The minimally processed soy flour used in these diets is more like the soy foods in the Asian diet,” Helferich said.

“Dietary soy products that contained isoflavones in more purified forms were associated with greater tumor growth. These products are similar to the materials used in isoflavone-containing dietary supplements, which is how many Americans consume these compounds,” he added. 

RELATED STORIES:
Breast cancer diagnosis may not affect job   Weight gain worsens breast cancer survival   Fertility a worry for young breast cancer patients   Breast-conservation may be OK for inherited cancers   Promo for breast cream causes uproar in Thailand   Underactive Thyroid Cuts Breast Cancer Risk   Group therapy doesn’t extend breast cancer survival   Some Women Use Test To Determine Whether To Seek Chemotherapy   Breast cancer survival   Folate supplement may raise breast cancer risk   Confusion about cost may lower mammogram rates   Being active seen to up breast cancer survival

Comments

[ + Post Your Own ]

Now you're in the public comment zone. What follows is not Armenian Medical Network's stuff; it comes from other people and we don't vouch for it. A reminder: By using this Web site you agree to accept our Terms of Service. Click here to read the Rules of Engagement.

There are no comments for this entry yet. [ + Comment here + ]