Study evaluates prevalence of age-related macular degeneration in the United States

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An estimated 6.5 percent of Americans age 40 and older have the eye disease age-related macular degeneration, a lower rate than was reported 15 years ago, according to a report in the January issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

“Despite new medical and surgical interventions, age-related macular degeneration (AMD) remains an important cause of loss of vision in the United States,” the authors write as background information in the article. The last nationally representative estimates of prevalence of AMD were based on the 1988-1994 Third National Health and Nutrition Examination Survey (NHANES III).

To update these estimates, Ronald Klein, M.D., M.P.H., of University of Wisconsin School of Medicine and Public Health, Madison, and colleagues analyzed data from the 2005 to 2008 NHANES. A total of 7,081 individuals age 40 or older were selected to participate and had photographs taken of both eyes. Digital images of the eyes were assessed for signs of AMD, including drusen (tiny yellow or white deposits in the retina), pigment changes and atrophy in the retina and surrounding tissue.

The overall prevalence of AMD among adults age 40 and older was an estimated 6.5 percent, which represented a decrease from the 9.4 percent reported in the 1988 to 1994 survey. The estimated prevalence of late (more advanced) AMD was 0.8 percent. Non-Hispanic black individuals age 60 and older had a lower prevalence of any AMD than non-Hispanic white individuals of the same age.

“These estimates are consistent with a decreasing incidence of AMD reported in another population-based study and have important public health implications,” the authors conclude. “The decreasing prevalence of AMD may reflect recent change in the frequency of smoking and other exposures such as diet, physical activity and blood pressure associated with AMD. It remains to be seen whether public health programs designed to increase awareness of the relationships of these exposures to AMD in patients at risk and their physicians and eye care providers will continue to result in further decline of the prevalence of AMD in the population.”

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(Arch Ophthalmol. 2011;129[1]:75-80. Available pre-embargo to the media at http://www.jamamedia.org.)

Editor’s Note: This research was supported by a National Health and Nutrition Examination survey contract, which provided funding for the entire study including collection and analyses of data. Additional support was provided by Senior Scientific Investigator Awards from Research to Prevent Blindness. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

To contact Ronald Klein, M.D., M.P.H., call Dian Land at 608-261-1034 or e-mail .

For more information, contact JAMA/Archives Media Relations at 312/464-JAMA (5262) or e-mail .

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Contact: Dian Land

608-261-1034
JAMA and Archives Journals

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