Pharmacokinetics of tramadol in children

The recent studies focusing on the pharmacokinetics of tramadol in children contributed to the increase popularity of tramadol as an analgesic alternative in clinical practice. Tramadol is a racemic mixture of 2 enantiomers that have comparable pharmacokinetic profile and this lack of difference is also observed with their main active metabolite, O-demethyl tramadol (M1).

The serum concentrations of this metabolite depend largely on the activity of the cytochrome P450 and particularly of the enzyme CYP2D6 which reaches its maturity in the newborn. Nevertheless, the interindividual variability observed in the pharmacokinetics of tramadol and consequently in the pharmacodynamic profile is mainly due to the genetic polymorphism of cytochrome P450.

Mots clés: Pharmacocinétique; Tramadol; Pédiatrie; Métabolisme; Cytochrome P450
Keywords: Pharmacokinetic; Tramadol; Children; Metabolism; Cytochrome P450

Travail présenté lors du Congrès annuel de l’Association des anesthésistes–réanimateurs pédiatriques d’expression française (Adarpef), Annecy 23/24 mars 2007.

S. Saudana and W. Habre
Unité d’anesthésie pédiatrique, hôpital des enfants, hôpitaux universitaires de Genève, 6, rue Willy-Donzé, 1205 Genève, Suisse

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